Narrow-band imaging endoscopy to assess mucosal angiogenesis in inflammatory bowel disease: A pilot study

Research output: Contribution to journalArticle

Abstract

AIM: To investigate whether narrow band imaging (NBI) is a useful tool for the nn vivo detection of angiogenesis in inflammatory bowel disease (IBD) patients. METHODS: Conventional and NBI colonoscopy was performed in 14 patients with colonic inflammation (8 ulcerative colitis and 6 Crohn's disease). Biopsy samples were taken and CD31 expression was assayed immuno-histochemically; microvascular density was assessed by vessel count. RESULTS: In areas that were endoscopically normal but positive on NBI, there was a significant (P <0.05) increase in angiogenesis (12 ± 1 vessels/field vs 18 ± 2 vessels/field) compared with areas negative on NBI. In addition, in areas that were inflamed on white light endoscopy and positive on NBI, there was a significant (P <0.01) increase in vessel density (24 ± 7 vessels/field) compared with NBI-negative areas. CONCLUSION: NBI may allow nn vivo imaging of intestinal angiogenesis in IBD patients.

Original languageEnglish
Pages (from-to)2396-2400
Number of pages5
JournalWorld Journal of Gastroenterology
Volume16
Issue number19
DOIs
Publication statusPublished - May 21 2010

Keywords

  • Angiogenesis
  • Crohn's disease
  • Inflammatory bowel disease
  • Narrow-band imaging
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

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