Abstract
The systemic availability of glucagon and human calcitonin given intranasally to healthy volunteers as spray solutions or powders has been examined. Glucagon was absorbed only when surfactants were used, and 9-lauryl ether (as a spray) and sodium glycocholate (as spray or powder) were equally active. Calcitonin was poorly absorbed when given alone but the surfactants dihydrofusinate (as spray or powder) and glycocholate (as a spray) were equally active in promoting absorption. Thus, enhancers are required to obtain significant nasal absorption of glucagon and calcitonin and powders and spray solutions did not differ in terms of systemic availability.
Original language | English |
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Pages (from-to) | 427-430 |
Number of pages | 4 |
Journal | European Journal of Clinical Pharmacology |
Volume | 37 |
Issue number | 4 |
DOIs | |
Publication status | Published - Jul 1989 |
Keywords
- 9-lauryl ether
- adverse effects
- availability
- calcitonin
- dihydrofusinate
- glucagon
- nasal application
- powders
- sodium glycocholate
- spray solution
- surfactants
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmacology (medical)