Nasal cytokine modulation by montelukast in allergic children: A pilot study

G. Ciprandi, F. Frati, F. Marcucci, L. Sensi, M. A. Tosca, M. Milanese, V. Ricca

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Allergic rhinitis and asthma are characterized by chronic inflammation due to a Th2 cytokine polarization. Leukotrienes receptor antagonists have been shown to be effective in both diseases. Objective: Aim of the study was to evaluate the modulation by the antileukotriene montelukast on Th2 and Th1 cytokines in allergic rhinitis. Methods: Fourteen school children affected by persistent allergic rhinitis (PAR) and exercise-induced asthma (EIA) underwent a nasal lavage before and after a two-week treatment with montelukast. A panel of cytokines, including IL4, IL13, and IFNγ, was measured by immunoassay on nasal lavage samples. Results: Montelukast treatment induced a significant decrease of IL4 and IL13 levels (p

Original languageEnglish
Pages (from-to)295-299
Number of pages5
JournalEuropean Annals of Allergy and Clinical Immunology
Volume35
Issue number8
Publication statusPublished - Oct 2003

Fingerprint

montelukast
Nose
Nasal Lavage
Interleukin-13
Cytokines
Interleukin-4
Exercise-Induced Asthma
Leukotriene Antagonists
Immunoassay
Asthma
Inflammation
Therapeutics
Allergic Rhinitis

Keywords

  • Children
  • Montelukast
  • Persistent allergic rhinitis
  • Th1 and Th2 cytokines

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Ciprandi, G., Frati, F., Marcucci, F., Sensi, L., Tosca, M. A., Milanese, M., & Ricca, V. (2003). Nasal cytokine modulation by montelukast in allergic children: A pilot study. European Annals of Allergy and Clinical Immunology, 35(8), 295-299.

Nasal cytokine modulation by montelukast in allergic children : A pilot study. / Ciprandi, G.; Frati, F.; Marcucci, F.; Sensi, L.; Tosca, M. A.; Milanese, M.; Ricca, V.

In: European Annals of Allergy and Clinical Immunology, Vol. 35, No. 8, 10.2003, p. 295-299.

Research output: Contribution to journalArticle

Ciprandi, G, Frati, F, Marcucci, F, Sensi, L, Tosca, MA, Milanese, M & Ricca, V 2003, 'Nasal cytokine modulation by montelukast in allergic children: A pilot study', European Annals of Allergy and Clinical Immunology, vol. 35, no. 8, pp. 295-299.
Ciprandi, G. ; Frati, F. ; Marcucci, F. ; Sensi, L. ; Tosca, M. A. ; Milanese, M. ; Ricca, V. / Nasal cytokine modulation by montelukast in allergic children : A pilot study. In: European Annals of Allergy and Clinical Immunology. 2003 ; Vol. 35, No. 8. pp. 295-299.
@article{62a76463f886461a95fa5c117189ca1e,
title = "Nasal cytokine modulation by montelukast in allergic children: A pilot study",
abstract = "Background: Allergic rhinitis and asthma are characterized by chronic inflammation due to a Th2 cytokine polarization. Leukotrienes receptor antagonists have been shown to be effective in both diseases. Objective: Aim of the study was to evaluate the modulation by the antileukotriene montelukast on Th2 and Th1 cytokines in allergic rhinitis. Methods: Fourteen school children affected by persistent allergic rhinitis (PAR) and exercise-induced asthma (EIA) underwent a nasal lavage before and after a two-week treatment with montelukast. A panel of cytokines, including IL4, IL13, and IFNγ, was measured by immunoassay on nasal lavage samples. Results: Montelukast treatment induced a significant decrease of IL4 and IL13 levels (p",
keywords = "Children, Montelukast, Persistent allergic rhinitis, Th1 and Th2 cytokines",
author = "G. Ciprandi and F. Frati and F. Marcucci and L. Sensi and Tosca, {M. A.} and M. Milanese and V. Ricca",
year = "2003",
month = "10",
language = "English",
volume = "35",
pages = "295--299",
journal = "Allergie et Immunologie",
issn = "0397-9148",
publisher = "Mattioli 1885 S.p.A.",
number = "8",

}

TY - JOUR

T1 - Nasal cytokine modulation by montelukast in allergic children

T2 - A pilot study

AU - Ciprandi, G.

AU - Frati, F.

AU - Marcucci, F.

AU - Sensi, L.

AU - Tosca, M. A.

AU - Milanese, M.

AU - Ricca, V.

PY - 2003/10

Y1 - 2003/10

N2 - Background: Allergic rhinitis and asthma are characterized by chronic inflammation due to a Th2 cytokine polarization. Leukotrienes receptor antagonists have been shown to be effective in both diseases. Objective: Aim of the study was to evaluate the modulation by the antileukotriene montelukast on Th2 and Th1 cytokines in allergic rhinitis. Methods: Fourteen school children affected by persistent allergic rhinitis (PAR) and exercise-induced asthma (EIA) underwent a nasal lavage before and after a two-week treatment with montelukast. A panel of cytokines, including IL4, IL13, and IFNγ, was measured by immunoassay on nasal lavage samples. Results: Montelukast treatment induced a significant decrease of IL4 and IL13 levels (p

AB - Background: Allergic rhinitis and asthma are characterized by chronic inflammation due to a Th2 cytokine polarization. Leukotrienes receptor antagonists have been shown to be effective in both diseases. Objective: Aim of the study was to evaluate the modulation by the antileukotriene montelukast on Th2 and Th1 cytokines in allergic rhinitis. Methods: Fourteen school children affected by persistent allergic rhinitis (PAR) and exercise-induced asthma (EIA) underwent a nasal lavage before and after a two-week treatment with montelukast. A panel of cytokines, including IL4, IL13, and IFNγ, was measured by immunoassay on nasal lavage samples. Results: Montelukast treatment induced a significant decrease of IL4 and IL13 levels (p

KW - Children

KW - Montelukast

KW - Persistent allergic rhinitis

KW - Th1 and Th2 cytokines

UR - http://www.scopus.com/inward/record.url?scp=0242499148&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242499148&partnerID=8YFLogxK

M3 - Article

C2 - 14653048

AN - SCOPUS:0242499148

VL - 35

SP - 295

EP - 299

JO - Allergie et Immunologie

JF - Allergie et Immunologie

SN - 0397-9148

IS - 8

ER -