Nasal cytokine modulation by montelukast in allergic children: A pilot study

G. Ciprandi, F. Frati, F. Marcucci, L. Sensi, M. A. Tosca, M. Milanese, V. Ricca

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Background: Allergic rhinitis and asthma are characterized by chronic inflammation due to a Th2 cytokine polarization. Leukotrienes receptor antagonists have been shown to be effective in both diseases. Objective: Aim of the study was to evaluate the modulation by the antileukotriene montelukast on Th2 and Th1 cytokines in allergic rhinitis. Methods: Fourteen school children affected by persistent allergic rhinitis (PAR) and exercise-induced asthma (EIA) underwent a nasal lavage before and after a two-week treatment with montelukast. A panel of cytokines, including IL4, IL13, and IFNγ, was measured by immunoassay on nasal lavage samples. Results: Montelukast treatment induced a significant decrease of IL4 and IL13 levels (p

Original languageEnglish
Pages (from-to)295-299
Number of pages5
JournalEuropean Annals of Allergy and Clinical Immunology
Issue number8
Publication statusPublished - Oct 2003



  • Children
  • Montelukast
  • Persistent allergic rhinitis
  • Th1 and Th2 cytokines

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Ciprandi, G., Frati, F., Marcucci, F., Sensi, L., Tosca, M. A., Milanese, M., & Ricca, V. (2003). Nasal cytokine modulation by montelukast in allergic children: A pilot study. European Annals of Allergy and Clinical Immunology, 35(8), 295-299.