Nasal decongestion test in allergic rhinitis: Definition of responder

Giorgio Ciprandi, Ignazio Cirillo, Catherine Klersy, Anna Maria Castellazzi, Salvatore Barberi, Gian Luigi Marseglia

Research output: Contribution to journalArticle

Abstract

Background: Nasal airflow, as measured by rhinomanometry, is frequently impaired in allergic rhinitis (AR). The decongestion test evaluates whether the application of an intranasal vasoconstrictor drug increases nasal airflow. Objective: The aim of this study was to define the characteristics of decongestion test responders. Methods: 123 subjects (112 males and 11 females, mean age 22.9 ± 5.7 years) with AR were studied. Nasal eosinophils, rhinomanometry, and decongestion test were assessed in all subjects. Results: The optimal cut-off for % variation of nasal airflow and nasal eosinophils > 5 was = 34.4, with sensibility = 82.7% (95%CI 73.7-89.6) and specificity = 80% (95%CI 59.3-93.1). Conclusions: The clinical relevance of this study is that non-responders may have a likely moderate-severe allergic inflammation that should be adequately evaluated and treated.

Original languageEnglish
Pages (from-to)372-374
Number of pages3
JournalInternational Immunopharmacology
Volume7
Issue number3
DOIs
Publication statusPublished - Mar 2007

Keywords

  • Allergic rhinitis
  • Decongestion test
  • Eosinophils
  • Nasal airflow
  • Nasal obstruction

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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