Nasal obstruction is the key symptom in hay fever patients

Giorgio Ciprandi, Ignazio Cirillo, Catherine Klersy, Gian Luigi Marseglia, Davide Caimmi, Andrea Vizzaccaro

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Allergic rhinitis is characterized by a Th2-dependent inflammation. Nasal obstruction largely depends on allergic inflammation. OBJECTIVE: The aim of this study was to evaluate the possible role of the symptom nasal obstruction in assessing patients with hay fever. METHODS: Fifty patients (mean age, 23.7 ± 4.9 years) with hay fever were evaluated both during and outside pollen season. All of them had moderate-severe grade of nasal obstruction. Total symptom score (TSS), rhinomanometry, nasal lavage, nasal scraping, spirometry, and methacholine bronchial challenge were performed in all subjects. RESULTS: During the pollen season, patients with severe nasal obstruction showed significantly higher values of TSS, IL-4, IL-5, IL-8, nasal eosinophils and neutrophils, and significantly lower values of nasal airflow, IFNγ, FEV1, FVC, and FEF 25-75 in comparison with patients with moderate nasal obstruction. Twenty (83%) patients with severe nasal obstruction showed bronchial hyperreactivity (BHR), whereas only 6 (25%) patients with moderate nasal obstruction had BHR. Outside the pollen season overlapping results were observed. CONCLUSIONS: This study provides evidence about the key role played by nasal obstruction in assessing patients with allergic rhinitis.

Original languageEnglish
Pages (from-to)429-435
Number of pages7
JournalOtolaryngology - Head and Neck Surgery
Volume133
Issue number3
DOIs
Publication statusPublished - Sep 2005

ASJC Scopus subject areas

  • Otorhinolaryngology

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