Nasal polyposis in Churg-Strauss syndrome

Andrea Bacciu, Carlo Buzio, Davide Giordano, Enrico Pasanisi, Vincenzo Vincenti, Giuseppe Mercante, Chiara Grasselli, Salvatore Bacciu

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: Churg-Strauss syndrome (CSS) is a systemic vasculitic disorder of unknown etiology that affects small-to-medium-size blood vessels. Patients affected by CSS frequently show ear, nose, and throat manifestations, which are often present at the time of disease onset. The purpose of this study was to determine the frequency of nasal polyposis in a series of 29 patients with CSS and to correlate the nasal findings to the total health situation of these patients. STUDY DESIGN: Retrospective analysis. SETTING: Department of Otolaryngology and Department of Clinical Medicine, Nephrology and Health Science, University of Parma. METHODS: Twenty-nine patients with CSS were identified. Of the 29 patients, 17 (58.6%) had nasal polyposis and were enrolled in this study. The nasal polyps were graded according to the Lund and Mackay endoscopic and radiological classifications. RESULTS: At diagnosis, endoscopic intranasal evaluation identified nasal polyposis of grade 3 in nine cases (52.9%), grade 2 in six cases (35.2%), and grade 1 in the remaining case (5.8%). After corticosteroid and immunosuppressive therapy, clinical remission was achieved in 14 patients (82.3%), whereas 3 patients experienced a relapse. Posttreatment endoscopic evaluation showed a permanent disappearance (grade 0) of nasal polyps in eight patients (47%). The other nine patients (52.92%) were found to have a small polyp situated in the middle meatus (grade 1). CONCLUSIONS: Nasal polyposis in patients with CSS may represent the initial phase of the syndrome, though patients often have concurrent pulmonary disease. Corticosteroid therapy either alone or combined with immunosuppressive drugs usually yielded improvement or stabilization.

Original languageEnglish
Pages (from-to)325-329
Number of pages5
JournalLaryngoscope
Volume118
Issue number2
DOIs
Publication statusPublished - Feb 2008

Fingerprint

Churg-Strauss Syndrome
Nose
Nasal Polyps
Immunosuppressive Agents
Adrenal Cortex Hormones
Nephrology
Clinical Medicine
Health
Otolaryngology
Pharynx
Polyps
Lung Diseases
Ear
Blood Vessels

Keywords

  • Allergic angiitis
  • Churg-Strauss syndrome
  • Nasal polyposis
  • Systemic vasculitis

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Bacciu, A., Buzio, C., Giordano, D., Pasanisi, E., Vincenti, V., Mercante, G., ... Bacciu, S. (2008). Nasal polyposis in Churg-Strauss syndrome. Laryngoscope, 118(2), 325-329. https://doi.org/10.1097/MLG.0b013e318159889d

Nasal polyposis in Churg-Strauss syndrome. / Bacciu, Andrea; Buzio, Carlo; Giordano, Davide; Pasanisi, Enrico; Vincenti, Vincenzo; Mercante, Giuseppe; Grasselli, Chiara; Bacciu, Salvatore.

In: Laryngoscope, Vol. 118, No. 2, 02.2008, p. 325-329.

Research output: Contribution to journalArticle

Bacciu, A, Buzio, C, Giordano, D, Pasanisi, E, Vincenti, V, Mercante, G, Grasselli, C & Bacciu, S 2008, 'Nasal polyposis in Churg-Strauss syndrome', Laryngoscope, vol. 118, no. 2, pp. 325-329. https://doi.org/10.1097/MLG.0b013e318159889d
Bacciu A, Buzio C, Giordano D, Pasanisi E, Vincenti V, Mercante G et al. Nasal polyposis in Churg-Strauss syndrome. Laryngoscope. 2008 Feb;118(2):325-329. https://doi.org/10.1097/MLG.0b013e318159889d
Bacciu, Andrea ; Buzio, Carlo ; Giordano, Davide ; Pasanisi, Enrico ; Vincenti, Vincenzo ; Mercante, Giuseppe ; Grasselli, Chiara ; Bacciu, Salvatore. / Nasal polyposis in Churg-Strauss syndrome. In: Laryngoscope. 2008 ; Vol. 118, No. 2. pp. 325-329.
@article{6668b1d6525847ae910d95becd449fae,
title = "Nasal polyposis in Churg-Strauss syndrome",
abstract = "OBJECTIVES: Churg-Strauss syndrome (CSS) is a systemic vasculitic disorder of unknown etiology that affects small-to-medium-size blood vessels. Patients affected by CSS frequently show ear, nose, and throat manifestations, which are often present at the time of disease onset. The purpose of this study was to determine the frequency of nasal polyposis in a series of 29 patients with CSS and to correlate the nasal findings to the total health situation of these patients. STUDY DESIGN: Retrospective analysis. SETTING: Department of Otolaryngology and Department of Clinical Medicine, Nephrology and Health Science, University of Parma. METHODS: Twenty-nine patients with CSS were identified. Of the 29 patients, 17 (58.6{\%}) had nasal polyposis and were enrolled in this study. The nasal polyps were graded according to the Lund and Mackay endoscopic and radiological classifications. RESULTS: At diagnosis, endoscopic intranasal evaluation identified nasal polyposis of grade 3 in nine cases (52.9{\%}), grade 2 in six cases (35.2{\%}), and grade 1 in the remaining case (5.8{\%}). After corticosteroid and immunosuppressive therapy, clinical remission was achieved in 14 patients (82.3{\%}), whereas 3 patients experienced a relapse. Posttreatment endoscopic evaluation showed a permanent disappearance (grade 0) of nasal polyps in eight patients (47{\%}). The other nine patients (52.92{\%}) were found to have a small polyp situated in the middle meatus (grade 1). CONCLUSIONS: Nasal polyposis in patients with CSS may represent the initial phase of the syndrome, though patients often have concurrent pulmonary disease. Corticosteroid therapy either alone or combined with immunosuppressive drugs usually yielded improvement or stabilization.",
keywords = "Allergic angiitis, Churg-Strauss syndrome, Nasal polyposis, Systemic vasculitis",
author = "Andrea Bacciu and Carlo Buzio and Davide Giordano and Enrico Pasanisi and Vincenzo Vincenti and Giuseppe Mercante and Chiara Grasselli and Salvatore Bacciu",
year = "2008",
month = "2",
doi = "10.1097/MLG.0b013e318159889d",
language = "English",
volume = "118",
pages = "325--329",
journal = "Laryngoscope",
issn = "0023-852X",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Nasal polyposis in Churg-Strauss syndrome

AU - Bacciu, Andrea

AU - Buzio, Carlo

AU - Giordano, Davide

AU - Pasanisi, Enrico

AU - Vincenti, Vincenzo

AU - Mercante, Giuseppe

AU - Grasselli, Chiara

AU - Bacciu, Salvatore

PY - 2008/2

Y1 - 2008/2

N2 - OBJECTIVES: Churg-Strauss syndrome (CSS) is a systemic vasculitic disorder of unknown etiology that affects small-to-medium-size blood vessels. Patients affected by CSS frequently show ear, nose, and throat manifestations, which are often present at the time of disease onset. The purpose of this study was to determine the frequency of nasal polyposis in a series of 29 patients with CSS and to correlate the nasal findings to the total health situation of these patients. STUDY DESIGN: Retrospective analysis. SETTING: Department of Otolaryngology and Department of Clinical Medicine, Nephrology and Health Science, University of Parma. METHODS: Twenty-nine patients with CSS were identified. Of the 29 patients, 17 (58.6%) had nasal polyposis and were enrolled in this study. The nasal polyps were graded according to the Lund and Mackay endoscopic and radiological classifications. RESULTS: At diagnosis, endoscopic intranasal evaluation identified nasal polyposis of grade 3 in nine cases (52.9%), grade 2 in six cases (35.2%), and grade 1 in the remaining case (5.8%). After corticosteroid and immunosuppressive therapy, clinical remission was achieved in 14 patients (82.3%), whereas 3 patients experienced a relapse. Posttreatment endoscopic evaluation showed a permanent disappearance (grade 0) of nasal polyps in eight patients (47%). The other nine patients (52.92%) were found to have a small polyp situated in the middle meatus (grade 1). CONCLUSIONS: Nasal polyposis in patients with CSS may represent the initial phase of the syndrome, though patients often have concurrent pulmonary disease. Corticosteroid therapy either alone or combined with immunosuppressive drugs usually yielded improvement or stabilization.

AB - OBJECTIVES: Churg-Strauss syndrome (CSS) is a systemic vasculitic disorder of unknown etiology that affects small-to-medium-size blood vessels. Patients affected by CSS frequently show ear, nose, and throat manifestations, which are often present at the time of disease onset. The purpose of this study was to determine the frequency of nasal polyposis in a series of 29 patients with CSS and to correlate the nasal findings to the total health situation of these patients. STUDY DESIGN: Retrospective analysis. SETTING: Department of Otolaryngology and Department of Clinical Medicine, Nephrology and Health Science, University of Parma. METHODS: Twenty-nine patients with CSS were identified. Of the 29 patients, 17 (58.6%) had nasal polyposis and were enrolled in this study. The nasal polyps were graded according to the Lund and Mackay endoscopic and radiological classifications. RESULTS: At diagnosis, endoscopic intranasal evaluation identified nasal polyposis of grade 3 in nine cases (52.9%), grade 2 in six cases (35.2%), and grade 1 in the remaining case (5.8%). After corticosteroid and immunosuppressive therapy, clinical remission was achieved in 14 patients (82.3%), whereas 3 patients experienced a relapse. Posttreatment endoscopic evaluation showed a permanent disappearance (grade 0) of nasal polyps in eight patients (47%). The other nine patients (52.92%) were found to have a small polyp situated in the middle meatus (grade 1). CONCLUSIONS: Nasal polyposis in patients with CSS may represent the initial phase of the syndrome, though patients often have concurrent pulmonary disease. Corticosteroid therapy either alone or combined with immunosuppressive drugs usually yielded improvement or stabilization.

KW - Allergic angiitis

KW - Churg-Strauss syndrome

KW - Nasal polyposis

KW - Systemic vasculitis

UR - http://www.scopus.com/inward/record.url?scp=40949137460&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40949137460&partnerID=8YFLogxK

U2 - 10.1097/MLG.0b013e318159889d

DO - 10.1097/MLG.0b013e318159889d

M3 - Article

C2 - 17989571

AN - SCOPUS:40949137460

VL - 118

SP - 325

EP - 329

JO - Laryngoscope

JF - Laryngoscope

SN - 0023-852X

IS - 2

ER -