TY - JOUR
T1 - Nasal resistance and allergic inflammation depend on allergen type
AU - Gelardi, Matteo
AU - Maselli Del Giudice, Alessandro
AU - Candreva, Teresa
AU - Fiorella, Maria Luisa
AU - Allen, Michaela
AU - Klersy, Catherine
AU - Marseglia, Gian Luigi
AU - Ciprandi, Giorgio
PY - 2006/11
Y1 - 2006/11
N2 - Background: Allergic rhinitis is characterized by inflammatory cell infiltrate and increased nasal airflow resistance. Objective: The aim of this study was to evaluate the relationship between sensitization type, inflammatory cell pattern, and nasal airflow resistance in a group of rhinitics with monosensitization. Methods: Seventy-seven subjects (40 males and 37 females, with a mean age of 33 ± 4.4 years) suffering from allergic rhinitis were studied. Skin prick test, nasal cytology and electronic rhinomanometry were assessed in all subjects. Results: The number of subjects monosensitized to house dust mites was 23, to grasses 20, to cypress 17, to Parietaria 11, and to olive tree 6. Significant differences were observed between each type of allergen sensitization concerning both the nasal airflow resistance (p = 0.002) and the nasal cytology pattern: eosinophils (p = 0.004), degranulated eosinophils (p = 0.002), mast cells (p = 0.006) and degranulated mast cells (p = 0.008). Furthermore, goblet cells were higher in house dust mite-sensitized subjects compared with the pollen-sensitized group (p = 0.018), in which a prevalence of eosinophils, degranulated eosinophils, mast cells and degranulated mast cells was observed (p = 0.049, p <0.001, p = 0.022 and p = 0.007, respectively). Nasal resistances were higher in the pollen group (p = 0.001). Conclusions: This study provides evidence that inflammatory cell pattern and nasal resistance depend on the type of allergen sensitization.
AB - Background: Allergic rhinitis is characterized by inflammatory cell infiltrate and increased nasal airflow resistance. Objective: The aim of this study was to evaluate the relationship between sensitization type, inflammatory cell pattern, and nasal airflow resistance in a group of rhinitics with monosensitization. Methods: Seventy-seven subjects (40 males and 37 females, with a mean age of 33 ± 4.4 years) suffering from allergic rhinitis were studied. Skin prick test, nasal cytology and electronic rhinomanometry were assessed in all subjects. Results: The number of subjects monosensitized to house dust mites was 23, to grasses 20, to cypress 17, to Parietaria 11, and to olive tree 6. Significant differences were observed between each type of allergen sensitization concerning both the nasal airflow resistance (p = 0.002) and the nasal cytology pattern: eosinophils (p = 0.004), degranulated eosinophils (p = 0.002), mast cells (p = 0.006) and degranulated mast cells (p = 0.008). Furthermore, goblet cells were higher in house dust mite-sensitized subjects compared with the pollen-sensitized group (p = 0.018), in which a prevalence of eosinophils, degranulated eosinophils, mast cells and degranulated mast cells was observed (p = 0.049, p <0.001, p = 0.022 and p = 0.007, respectively). Nasal resistances were higher in the pollen group (p = 0.001). Conclusions: This study provides evidence that inflammatory cell pattern and nasal resistance depend on the type of allergen sensitization.
KW - Allergen sensitization
KW - Allergic rhinitis classifications
KW - Nasal airflow resistance
KW - Nasal cytology
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U2 - 10.1159/000095465
DO - 10.1159/000095465
M3 - Article
C2 - 16943677
AN - SCOPUS:33751223177
VL - 141
SP - 384
EP - 389
JO - International Archives of Allergy and Immunology
JF - International Archives of Allergy and Immunology
SN - 1018-2438
IS - 4
ER -