Nasal resistance and allergic inflammation depend on allergen type

Matteo Gelardi, Alessandro Maselli Del Giudice, Teresa Candreva, Maria Luisa Fiorella, Michaela Allen, Catherine Klersy, Gian Luigi Marseglia, Giorgio Ciprandi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Allergic rhinitis is characterized by inflammatory cell infiltrate and increased nasal airflow resistance. Objective: The aim of this study was to evaluate the relationship between sensitization type, inflammatory cell pattern, and nasal airflow resistance in a group of rhinitics with monosensitization. Methods: Seventy-seven subjects (40 males and 37 females, with a mean age of 33 ± 4.4 years) suffering from allergic rhinitis were studied. Skin prick test, nasal cytology and electronic rhinomanometry were assessed in all subjects. Results: The number of subjects monosensitized to house dust mites was 23, to grasses 20, to cypress 17, to Parietaria 11, and to olive tree 6. Significant differences were observed between each type of allergen sensitization concerning both the nasal airflow resistance (p = 0.002) and the nasal cytology pattern: eosinophils (p = 0.004), degranulated eosinophils (p = 0.002), mast cells (p = 0.006) and degranulated mast cells (p = 0.008). Furthermore, goblet cells were higher in house dust mite-sensitized subjects compared with the pollen-sensitized group (p = 0.018), in which a prevalence of eosinophils, degranulated eosinophils, mast cells and degranulated mast cells was observed (p = 0.049, p <0.001, p = 0.022 and p = 0.007, respectively). Nasal resistances were higher in the pollen group (p = 0.001). Conclusions: This study provides evidence that inflammatory cell pattern and nasal resistance depend on the type of allergen sensitization.

Original languageEnglish
Pages (from-to)384-389
Number of pages6
JournalInternational Archives of Allergy and Immunology
Volume141
Issue number4
DOIs
Publication statusPublished - Nov 2006

Keywords

  • Allergen sensitization
  • Allergic rhinitis classifications
  • Nasal airflow resistance
  • Nasal cytology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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