Nasal seromucinous hamartoma (Microglandular adenosis of the nose): A morphological and molecular study of five cases

Andrea Ambrosini-Spaltro, Luca Morandi, Domini V. Spagnolo, Alberto Cavazza, Massimo Brisigotti, Stefania Damiani, Sanjiv Jain, Vincenzo Eusebi

Research output: Contribution to journalArticle

Abstract

Five cases of nasal seromucinous hamartoma were studied and their clinical, morphological, immunohistochemical and molecular data are reported. The patients, three females and two males, ranged in age from 49 to 66 years (mean 56 year, SD±7.91). All lesions were located in the nasal cavity. In four cases where follow-up was obtained, no recurrence was evident. In all cases, numerous small seromucinous tubules, embedded in a cellular stroma, were present in the lamina propria. Tubules were lined by one layer of cuboidal cells which displayed luminal phenotype positive for lysozyme and EMA in four, and S100 protein in all cases. Collagen IV and laminin positive basal lamina outlined the tubules which lacked basal cells. Stromal spindle cells present among tubules were immunoreactive for calponin in all cases and for alphasmooth muscle actin in four cases. DNA mutation analysis of mitochondrial D-loop region was performed by direct sequencing in order to verify the mutation rate of these lesions. The tubules of the five seromucinous hamartomas showed a higher mutation rate especially in heteroplasmy (0.52% homoplasmy, 2.02% heteroplasmy) in comparison to normal seromucinous glands which exhibited a lower mutation frequency (0.83%). This is considered a sign of a low cellular proliferation rate consistent with a benign process. It is concluded that nasal seromucinous hamartomas are benign glandular proliferations that may resemble microglandular adenosis of the breast. Their distinction from benign and malignant mimics is discussed.

Original languageEnglish
Pages (from-to)727-734
Number of pages8
JournalVirchows Archiv
Volume457
Issue number6
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Microglandular adenosis
  • Nasal cavity
  • Seromucinous hamartoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology
  • Molecular Biology

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    Ambrosini-Spaltro, A., Morandi, L., Spagnolo, D. V., Cavazza, A., Brisigotti, M., Damiani, S., Jain, S., & Eusebi, V. (2010). Nasal seromucinous hamartoma (Microglandular adenosis of the nose): A morphological and molecular study of five cases. Virchows Archiv, 457(6), 727-734. https://doi.org/10.1007/s00428-010-0984-7