Nasopharingeal polymorphous low-grade adenocarcinoma in a patient with non-functioning pituitary macroadenoma

Massimiliano Garzaro, G. Pecorari, V. Landolfo, P. Campisi, A. Reali, C. Giordano

Research output: Contribution to journalArticlepeer-review


Background: Polymorphous low grade adenocarcinoma (PLGA) is a rare malignant neoplasm of the minor salivary glands occurring in the fifth and sixth decade with a 2:1 female predominance. The nasal cavity is involved in less than 1% of cases. The incidence of clinically recognisable pituitary adenoma is 15 cases/million/year. The prevalence of non-functioning pituitary adenoma (NFPA) is estimated to be 70-90 cases/million. Both types of adenoma represent 20-45% of pituitary tumours. Case report: The report describes the first case of PLGA associated with NFPA, both incidentally diagnosed. Three months after the exeresis of the NFPA using a trans-sphenoidal approach, an endoscopic resection of the PLGA was performed. No recurrence was observed during a 13 months follow-up. Conclusions: Complete surgical excision is the preferred management for PLGA. Radiotherapy has not been demonstrated to be effective in treating PLGA. The prognosis is good with a very low rate of metastasis and local recurrence.

Original languageEnglish
Pages (from-to)59-62
Number of pages4
Issue number1
Publication statusPublished - Mar 2010


  • Nasopharynx
  • Pituitary non-functioning adenoma
  • Polymorphous low-grade adenocarcinoma
  • Surgical therapy

ASJC Scopus subject areas

  • Otorhinolaryngology


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