Nasopharynxkarzinom in einem europäischen Gebiet mit geringer Inzidenz: Eine prospektive Beobachtungsanalyse der Kopf- und Hals-Studiengruppe der Italienischen Gesellschaft für Radioonkologie (AIRO)

Translated title of the contribution: Nasopharyngeal carcinoma in a low incidence European area: A prospective observational analysis from the Head and Neck Study Group of the Italian Society of Radiation Oncology (AIRO)

S. Tonoli, D. Alterio, O. Caspiani, A. Bacigalupo, F. Bunkheila, M. Cianciulli, A. Merlotti, A. Podhradska, M. Rampino, D. Cante, L. Bruschieri, R. Gatta, S. M. Magrini

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To evaluate the outcomes with respect to long-term survival and toxicity in patients with nasopharyngeal carcinoma (NPC) treated in a European country with low incidence. Materials and methods: A prospective observational study carried out by the AIRO Head and Neck group in 12 Italian institutions included 136 consecutive patients treated with radiotherapy (RT) ± chemotherapy (CHT) for NPC (without distant metastasis) between January 1, 2008 and December 31, 2010. Results: The disease-specific survival (DSS), overall survival (OS), and disease-free survival (DFS) at 5 years were 92 (±2), 91 (±3), and 69 % (±5 %), respectively. Distant failure was the most frequent modality of relapse. The local, regional, and locoregional control at 5 years were 89 (±3), 93 (±3), and 84 % (±4 %), respectively. The incidence of acute and late toxicity and the correlations with different clinical/technical variables were analyzed. Neoadjuvant CHT prolongs radiotherapy overall treatment time (OTT) and decreases treatment adherence during concomitant chemoradiotherapy. An adequate minimum dose coverage to PTV(T) is a predictive variable well related to outcome. Conclusion: Our data do not substantially differ in terms of survival and toxicity outcomes from those reported in larger series of patients treated in countries with higher incidences of NPC. The T stage (TNM 2002 UICC classification) is predictive of DSS and OS. The GTV volume (T ± N) and an adequate minimum PTV(T) coverage dose (D95 %) were also identified as potential predictive variables. Sophisticated technologies of dose delivery (IMRT) with image-guided radiotherapy could help to obtain better minimum PTV(T) coverage dose with increased DFS; distant metastasis after treatment still remains an unresolved issue.

Translated title of the contributionNasopharyngeal carcinoma in a low incidence European area: A prospective observational analysis from the Head and Neck Study Group of the Italian Society of Radiation Oncology (AIRO)
Original languageGerman
Pages (from-to)931-943
Number of pages13
JournalStrahlentherapie und Onkologie
Volume192
Issue number12
DOIs
Publication statusPublished - Dec 1 2016

Keywords

  • Chemotherapy
  • Prognosis
  • Radiotherapy
  • Survival
  • Toxicity

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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