Nasopharyngeal carriage of Streptococcus pneumoniae in healthy children: Implications for the use of heptavalent pneumococcal conjugate vaccine

Paola Marchisio, Susanna Esposito, Gian Carlo Schito, Anna Marchese, Roberta Cavagna, Nicola Principi

Research output: Contribution to journalArticle

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Abstract

We assessed the prevalence of Streptococcus pneumoniae serotypes in the nasopharynx of healthy children, antimicrobial susceptibility patterns, risk factors for carriage, and the coverage of heptavalent pneumococcal conjugate vaccine. In 2,799 healthy infants and children, the S. pneumoniae carrier rate was 8.6% (serotypes 3, 19F, 23F, 19A, 6B, and 14 were most common). Most pneumococci (69.4%) were resistant to one or more antimicrobial classes. The rate of penicillin resistance was low (9.1%); macrolide resistance was high (52.1%). Overall, 63.2% of the isolates belonged to strains covered by the heptavalent pneumococcal vaccine. This percentage was higher in children

Original languageEnglish
Pages (from-to)479-484
Number of pages6
JournalEmerging Infectious Diseases
Volume8
Issue number5
Publication statusPublished - 2002

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Streptococcus pneumoniae
Penicillin Resistance
Pneumococcal Vaccines
Nasopharynx
Macrolides
Heptavalent Pneumococcal Conjugate Vaccine
Serogroup

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Nasopharyngeal carriage of Streptococcus pneumoniae in healthy children : Implications for the use of heptavalent pneumococcal conjugate vaccine. / Marchisio, Paola; Esposito, Susanna; Schito, Gian Carlo; Marchese, Anna; Cavagna, Roberta; Principi, Nicola.

In: Emerging Infectious Diseases, Vol. 8, No. 5, 2002, p. 479-484.

Research output: Contribution to journalArticle

Marchisio, Paola ; Esposito, Susanna ; Schito, Gian Carlo ; Marchese, Anna ; Cavagna, Roberta ; Principi, Nicola. / Nasopharyngeal carriage of Streptococcus pneumoniae in healthy children : Implications for the use of heptavalent pneumococcal conjugate vaccine. In: Emerging Infectious Diseases. 2002 ; Vol. 8, No. 5. pp. 479-484.
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