Nasopharyngeal carriage of Streptococcus pneumoniae in healthy children: Implications for the use of heptavalent pneumococcal conjugate vaccine

Paola Marchisio, Susanna Esposito, Gian Carlo Schito, Anna Marchese, Roberta Cavagna, Nicola Principi

Research output: Contribution to journalArticle

Abstract

We assessed the prevalence of Streptococcus pneumoniae serotypes in the nasopharynx of healthy children, antimicrobial susceptibility patterns, risk factors for carriage, and the coverage of heptavalent pneumococcal conjugate vaccine. In 2,799 healthy infants and children, the S. pneumoniae carrier rate was 8.6% (serotypes 3, 19F, 23F, 19A, 6B, and 14 were most common). Most pneumococci (69.4%) were resistant to one or more antimicrobial classes. The rate of penicillin resistance was low (9.1%); macrolide resistance was high (52.1%). Overall, 63.2% of the isolates belonged to strains covered by the heptavalent pneumococcal vaccine. This percentage was higher in children

Original languageEnglish
Pages (from-to)479-484
Number of pages6
JournalEmerging Infectious Diseases
Volume8
Issue number5
Publication statusPublished - 2002

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ASJC Scopus subject areas

  • Microbiology (medical)

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