Na+,K+-ATPase of gastric cells A target of Helicobacter pylori cytotoxic activity

V. Ricci, P. Sommi, E. Cova, R. Fiocca, M. Romano, K. J. Ivey, E. Solcia, U. Ventura

Research output: Contribution to journalArticlepeer-review


The present study shows a direct impairing action of a cytotoxin-producing Helicobacter pylori strain on the Na+,K--ATPase (evaluated as K+-dependent phosphatase activity) of human gastric epithelial cells in culture. The toxin itself is likely involved in this action which may also account for the cell edema found in vivo in Helicobacter pylori-colonized stomach.

Original languageEnglish
Pages (from-to)158-160
Number of pages3
JournalFEBS Letters
Issue number2
Publication statusPublished - Nov 15 1993


  • Cell vacuolation
  • Cultured gastric cells
  • Cytotoxicity
  • Helicobacter pylori
  • K-dependent phosphatase activity
  • Na,K-ATPase

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology


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