Native hypovitaminosis d in ckd patients: From experimental evidence to clinical practice

Carlo Alfieri, Oksana Ruzhytska, Simone Vettoretti, Lara Caldiroli, Mario Cozzolino, Piergiorgio Messa

Research output: Contribution to journalReview articlepeer-review

Abstract

Native hypovitaminosis D (n-hVITD) is frequently found from the early stages of chronic kidney disease (CKD) and its prevalence increases with CKD progression. Even if the implications of n-hVITD in chronic kidney disease-mineral bone disorder (CKD-MBD) have been extensively characterized in the literature, there is a lot of debate nowadays about the so called “unconventional effects” of native vitamin D (25(OH)VitD) supplementation in CKD patients. In this review, highlights of the dimension of the problem of n-hVITD in CKD stages 2–5 ND patients will be presented. In addition, it will focus on the “unconventional effects” of 25(OH)VitD supplementation, the clinical impact of n-hVITD and the most significant interventional studies regarding 25(OH)VitD supplementation in CKD stages 2–5 ND.

Original languageEnglish
Article number1918
JournalNutrients
Volume11
Issue number8
DOIs
Publication statusPublished - Aug 1 2019

Keywords

  • Cardiovascular risk
  • CKD
  • Mineral metabolism
  • Vitamin D
  • Vitamin D supplementation

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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