Native hypovitaminosis d in ckd patients: From experimental evidence to clinical practice

Carlo Alfieri; Oksana Ruzhytska; Simone Vettoretti; Lara Caldiroli; Mario Cozzolino; Piergiorgio Messa

doi:10.3390/nu11081918

Native hypovitaminosis d in ckd patients: From experimental evidence to clinical practice

Carlo Alfieri, Oksana Ruzhytska, Simone Vettoretti, Lara Caldiroli, Mario Cozzolino, Piergiorgio Messa

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Review article › peer-review

Abstract

Native hypovitaminosis D (n-hVITD) is frequently found from the early stages of chronic kidney disease (CKD) and its prevalence increases with CKD progression. Even if the implications of n-hVITD in chronic kidney disease-mineral bone disorder (CKD-MBD) have been extensively characterized in the literature, there is a lot of debate nowadays about the so called “unconventional effects” of native vitamin D (25(OH)VitD) supplementation in CKD patients. In this review, highlights of the dimension of the problem of n-hVITD in CKD stages 2–5 ND patients will be presented. In addition, it will focus on the “unconventional effects” of 25(OH)VitD supplementation, the clinical impact of n-hVITD and the most significant interventional studies regarding 25(OH)VitD supplementation in CKD stages 2–5 ND.

Original language	English
Article number	1918
Journal	Nutrients
Volume	11
Issue number	8
DOIs	https://doi.org/10.3390/nu11081918
Publication status	Published - Aug 1 2019

Keywords

Cardiovascular risk
CKD
Mineral metabolism
Vitamin D
Vitamin D supplementation

ASJC Scopus subject areas

Food Science
Nutrition and Dietetics

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abstract = "Native hypovitaminosis D (n-hVITD) is frequently found from the early stages of chronic kidney disease (CKD) and its prevalence increases with CKD progression. Even if the implications of n-hVITD in chronic kidney disease-mineral bone disorder (CKD-MBD) have been extensively characterized in the literature, there is a lot of debate nowadays about the so called “unconventional effects” of native vitamin D (25(OH)VitD) supplementation in CKD patients. In this review, highlights of the dimension of the problem of n-hVITD in CKD stages 2–5 ND patients will be presented. In addition, it will focus on the “unconventional effects” of 25(OH)VitD supplementation, the clinical impact of n-hVITD and the most significant interventional studies regarding 25(OH)VitD supplementation in CKD stages 2–5 ND.",

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AU - Caldiroli, Lara

AU - Cozzolino, Mario

AU - Messa, Piergiorgio

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