Abstract
Native hypovitaminosis D (n-hVITD) is frequently found from the early stages of chronic kidney disease (CKD) and its prevalence increases with CKD progression. Even if the implications of n-hVITD in chronic kidney disease-mineral bone disorder (CKD-MBD) have been extensively characterized in the literature, there is a lot of debate nowadays about the so called “unconventional effects” of native vitamin D (25(OH)VitD) supplementation in CKD patients. In this review, highlights of the dimension of the problem of n-hVITD in CKD stages 2–5 ND patients will be presented. In addition, it will focus on the “unconventional effects” of 25(OH)VitD supplementation, the clinical impact of n-hVITD and the most significant interventional studies regarding 25(OH)VitD supplementation in CKD stages 2–5 ND.
Original language | English |
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Article number | 1918 |
Journal | Nutrients |
Volume | 11 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 1 2019 |
Keywords
- Cardiovascular risk
- CKD
- Mineral metabolism
- Vitamin D
- Vitamin D supplementation
ASJC Scopus subject areas
- Food Science
- Nutrition and Dietetics