TY - JOUR
T1 - Natriuretic peptides and other biomarkers in chronic heart failure
T2 - From BNP, NT-proBNP, and MR-proANP to routine biochemical markers
AU - Lainscak, Mitja
AU - von Haehling, Stephan
AU - Anker, Stefan D.
PY - 2009/3/6
Y1 - 2009/3/6
N2 - Cardiac biomarkers play an important role in heart failure. The family of natriuretic peptides, especially B-type natriuretic peptide, was identified as a valued diagnostic and prognostic tool. Not unexpectedly, the natriuretic peptides fail to fulfill all the criteria of an ideal biochemical marker. The quest for a single marker or a combination is therefore still on and several established, widely available biomarkers might have been overlooked in the field of heart failure. This review puts forward some of those biomarkers, and we speculate on the possible roles of combining two or more biomarkers. In that sense, any blood parameter including hemoglobin, cholesterol, uric acid, and recently identified proteins might function as a biomarker. Additionally, several biomarkers are discussed and we try to anticipate their diagnostic and prognostic value along with the natriuretic peptides and established biomarkers. Finally, we speculate about the potential of sharing the biomarkers over a variety of chronic diseases with similar pathophysiology.
AB - Cardiac biomarkers play an important role in heart failure. The family of natriuretic peptides, especially B-type natriuretic peptide, was identified as a valued diagnostic and prognostic tool. Not unexpectedly, the natriuretic peptides fail to fulfill all the criteria of an ideal biochemical marker. The quest for a single marker or a combination is therefore still on and several established, widely available biomarkers might have been overlooked in the field of heart failure. This review puts forward some of those biomarkers, and we speculate on the possible roles of combining two or more biomarkers. In that sense, any blood parameter including hemoglobin, cholesterol, uric acid, and recently identified proteins might function as a biomarker. Additionally, several biomarkers are discussed and we try to anticipate their diagnostic and prognostic value along with the natriuretic peptides and established biomarkers. Finally, we speculate about the potential of sharing the biomarkers over a variety of chronic diseases with similar pathophysiology.
KW - Cachexia
KW - Cholesterol
KW - Heart failure
KW - Hemoglobin
KW - Natriuretic peptides
KW - Uric acid
UR - http://www.scopus.com/inward/record.url?scp=60749107183&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=60749107183&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2008.11.149
DO - 10.1016/j.ijcard.2008.11.149
M3 - Article
C2 - 19144431
AN - SCOPUS:60749107183
VL - 132
SP - 303
EP - 311
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 3
ER -