TY - JOUR
T1 - Natural β-interferon and androgen receptors inprostatic cancer cells
AU - Sica, Gigliola
AU - Fabbroni, L.
AU - Dell’Acqua, G.
AU - Iacopino, F.
AU - Marchetti, P.
AU - Cacciatore, M.
AU - Pavone-Macaluso, M.
PY - 1991
Y1 - 1991
N2 - Both PC-3 and DU-145 cell lines are androgen-insensitive, but, in our experience, they contain androgen receptors (AR). Treatment of these cells with natural β-interferon at aconcentration of 1, 000 IU/ml of culture medium determines an increase of AR (evaluated by a whole-cell assay), statistically significant with respect to control. Androgen unresponsiveness of our cells could be due to an AR level which is lower than that present in hormone-sensitive prostatic cancer cell lines, such as LNCaP cells. For this reason, interferon-promoted AR increase merits further investigation, even if other defects in receptor mechanism, responsible for hormone insensitivity, cannot be excluded.
AB - Both PC-3 and DU-145 cell lines are androgen-insensitive, but, in our experience, they contain androgen receptors (AR). Treatment of these cells with natural β-interferon at aconcentration of 1, 000 IU/ml of culture medium determines an increase of AR (evaluated by a whole-cell assay), statistically significant with respect to control. Androgen unresponsiveness of our cells could be due to an AR level which is lower than that present in hormone-sensitive prostatic cancer cell lines, such as LNCaP cells. For this reason, interferon-promoted AR increase merits further investigation, even if other defects in receptor mechanism, responsible for hormone insensitivity, cannot be excluded.
KW - Androgen receptors
KW - Prostatic cancer cells
KW - β-Interferon
UR - http://www.scopus.com/inward/record.url?scp=0025829541&partnerID=8YFLogxK
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U2 - 10.1159/000282123
DO - 10.1159/000282123
M3 - Article
C2 - 2053224
AN - SCOPUS:0025829541
VL - 46
SP - 159
EP - 162
JO - Urologia Internationalis
JF - Urologia Internationalis
SN - 0042-1138
IS - 2
ER -