Natural β-interferon and androgen receptors inprostatic cancer cells

Gigliola Sica, L. Fabbroni, G. Dell’Acqua, F. Iacopino, P. Marchetti, M. Cacciatore, M. Pavone-Macaluso

Research output: Contribution to journalArticlepeer-review


Both PC-3 and DU-145 cell lines are androgen-insensitive, but, in our experience, they contain androgen receptors (AR). Treatment of these cells with natural β-interferon at aconcentration of 1, 000 IU/ml of culture medium determines an increase of AR (evaluated by a whole-cell assay), statistically significant with respect to control. Androgen unresponsiveness of our cells could be due to an AR level which is lower than that present in hormone-sensitive prostatic cancer cell lines, such as LNCaP cells. For this reason, interferon-promoted AR increase merits further investigation, even if other defects in receptor mechanism, responsible for hormone insensitivity, cannot be excluded.

Original languageEnglish
Pages (from-to)159-162
Number of pages4
JournalUrologia Internationalis
Issue number2
Publication statusPublished - 1991


  • Androgen receptors
  • Prostatic cancer cells
  • β-Interferon

ASJC Scopus subject areas

  • Urology


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