Natural β-interferon and androgen receptors inprostatic cancer cells

Gigliola Sica; L. Fabbroni; G. Dell’Acqua; F. Iacopino; P. Marchetti; M. Cacciatore; M. Pavone-Macaluso

doi:10.1159/000282123

Natural β-interferon and androgen receptors inprostatic cancer cells

Gigliola Sica, L. Fabbroni, G. Dell’Acqua, F. Iacopino, P. Marchetti, M. Cacciatore, M. Pavone-Macaluso

Istituto Dermopatico dell'Immacolata , IDI

Research output: Contribution to journal › Article › peer-review

Abstract

Both PC-3 and DU-145 cell lines are androgen-insensitive, but, in our experience, they contain androgen receptors (AR). Treatment of these cells with natural β-interferon at aconcentration of 1, 000 IU/ml of culture medium determines an increase of AR (evaluated by a whole-cell assay), statistically significant with respect to control. Androgen unresponsiveness of our cells could be due to an AR level which is lower than that present in hormone-sensitive prostatic cancer cell lines, such as LNCaP cells. For this reason, interferon-promoted AR increase merits further investigation, even if other defects in receptor mechanism, responsible for hormone insensitivity, cannot be excluded.

Original language	English
Pages (from-to)	159-162
Number of pages	4
Journal	Urologia Internationalis
Volume	46
Issue number	2
DOIs	https://doi.org/10.1159/000282123
Publication status	Published - 1991

Keywords

Androgen receptors
Prostatic cancer cells
β-Interferon

ASJC Scopus subject areas

Urology

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10.1159/000282123

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abstract = "Both PC-3 and DU-145 cell lines are androgen-insensitive, but, in our experience, they contain androgen receptors (AR). Treatment of these cells with natural β-interferon at aconcentration of 1, 000 IU/ml of culture medium determines an increase of AR (evaluated by a whole-cell assay), statistically significant with respect to control. Androgen unresponsiveness of our cells could be due to an AR level which is lower than that present in hormone-sensitive prostatic cancer cell lines, such as LNCaP cells. For this reason, interferon-promoted AR increase merits further investigation, even if other defects in receptor mechanism, responsible for hormone insensitivity, cannot be excluded.",

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AU - Sica, Gigliola

AU - Fabbroni, L.

AU - Dell’Acqua, G.

AU - Iacopino, F.

AU - Marchetti, P.

AU - Cacciatore, M.

AU - Pavone-Macaluso, M.

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AB - Both PC-3 and DU-145 cell lines are androgen-insensitive, but, in our experience, they contain androgen receptors (AR). Treatment of these cells with natural β-interferon at aconcentration of 1, 000 IU/ml of culture medium determines an increase of AR (evaluated by a whole-cell assay), statistically significant with respect to control. Androgen unresponsiveness of our cells could be due to an AR level which is lower than that present in hormone-sensitive prostatic cancer cell lines, such as LNCaP cells. For this reason, interferon-promoted AR increase merits further investigation, even if other defects in receptor mechanism, responsible for hormone insensitivity, cannot be excluded.

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