Abstract
Both PC-3 and DU-145 cell lines are androgen-insensitive, but, in our experience, they contain androgen receptors (AR). Treatment of these cells with natural β-interferon at aconcentration of 1, 000 IU/ml of culture medium determines an increase of AR (evaluated by a whole-cell assay), statistically significant with respect to control. Androgen unresponsiveness of our cells could be due to an AR level which is lower than that present in hormone-sensitive prostatic cancer cell lines, such as LNCaP cells. For this reason, interferon-promoted AR increase merits further investigation, even if other defects in receptor mechanism, responsible for hormone insensitivity, cannot be excluded.
| Original language | English |
|---|---|
| Pages (from-to) | 159-162 |
| Number of pages | 4 |
| Journal | Urologia Internationalis |
| Volume | 46 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1991 |
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Keywords
- Androgen receptors
- Prostatic cancer cells
- β-Interferon
ASJC Scopus subject areas
- Urology
Cite this
Natural β-interferon and androgen receptors inprostatic cancer cells. / Sica, Gigliola; Fabbroni, L.; Dell’Acqua, G.; Iacopino, F.; Marchetti, P.; Cacciatore, M.; Pavone-Macaluso, M.
In: Urologia Internationalis, Vol. 46, No. 2, 1991, p. 159-162.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Natural β-interferon and androgen receptors inprostatic cancer cells
AU - Sica, Gigliola
AU - Fabbroni, L.
AU - Dell’Acqua, G.
AU - Iacopino, F.
AU - Marchetti, P.
AU - Cacciatore, M.
AU - Pavone-Macaluso, M.
PY - 1991
Y1 - 1991
N2 - Both PC-3 and DU-145 cell lines are androgen-insensitive, but, in our experience, they contain androgen receptors (AR). Treatment of these cells with natural β-interferon at aconcentration of 1, 000 IU/ml of culture medium determines an increase of AR (evaluated by a whole-cell assay), statistically significant with respect to control. Androgen unresponsiveness of our cells could be due to an AR level which is lower than that present in hormone-sensitive prostatic cancer cell lines, such as LNCaP cells. For this reason, interferon-promoted AR increase merits further investigation, even if other defects in receptor mechanism, responsible for hormone insensitivity, cannot be excluded.
AB - Both PC-3 and DU-145 cell lines are androgen-insensitive, but, in our experience, they contain androgen receptors (AR). Treatment of these cells with natural β-interferon at aconcentration of 1, 000 IU/ml of culture medium determines an increase of AR (evaluated by a whole-cell assay), statistically significant with respect to control. Androgen unresponsiveness of our cells could be due to an AR level which is lower than that present in hormone-sensitive prostatic cancer cell lines, such as LNCaP cells. For this reason, interferon-promoted AR increase merits further investigation, even if other defects in receptor mechanism, responsible for hormone insensitivity, cannot be excluded.
KW - Androgen receptors
KW - Prostatic cancer cells
KW - β-Interferon
UR - http://www.scopus.com/inward/record.url?scp=0025829541&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025829541&partnerID=8YFLogxK
U2 - 10.1159/000282123
DO - 10.1159/000282123
M3 - Article
VL - 46
SP - 159
EP - 162
JO - Urologia Internationalis
JF - Urologia Internationalis
SN - 0042-1138
IS - 2
ER -