Natural β-interferon and androgen receptors inprostatic cancer cells

Gigliola Sica, L. Fabbroni, G. Dell’Acqua, F. Iacopino, P. Marchetti, M. Cacciatore, M. Pavone-Macaluso

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Both PC-3 and DU-145 cell lines are androgen-insensitive, but, in our experience, they contain androgen receptors (AR). Treatment of these cells with natural β-interferon at aconcentration of 1, 000 IU/ml of culture medium determines an increase of AR (evaluated by a whole-cell assay), statistically significant with respect to control. Androgen unresponsiveness of our cells could be due to an AR level which is lower than that present in hormone-sensitive prostatic cancer cell lines, such as LNCaP cells. For this reason, interferon-promoted AR increase merits further investigation, even if other defects in receptor mechanism, responsible for hormone insensitivity, cannot be excluded.

Original languageEnglish
Pages (from-to)159-162
Number of pages4
JournalUrologia Internationalis
Volume46
Issue number2
DOIs
Publication statusPublished - 1991

Fingerprint

Interferon Receptors
Androgen Receptors
Interferons
Androgens
Neoplasms
Hormones
Cell Line
Culture Media
Prostatic Neoplasms

Keywords

  • Androgen receptors
  • Prostatic cancer cells
  • β-Interferon

ASJC Scopus subject areas

  • Urology

Cite this

Sica, G., Fabbroni, L., Dell’Acqua, G., Iacopino, F., Marchetti, P., Cacciatore, M., & Pavone-Macaluso, M. (1991). Natural β-interferon and androgen receptors inprostatic cancer cells. Urologia Internationalis, 46(2), 159-162. https://doi.org/10.1159/000282123

Natural β-interferon and androgen receptors inprostatic cancer cells. / Sica, Gigliola; Fabbroni, L.; Dell’Acqua, G.; Iacopino, F.; Marchetti, P.; Cacciatore, M.; Pavone-Macaluso, M.

In: Urologia Internationalis, Vol. 46, No. 2, 1991, p. 159-162.

Research output: Contribution to journalArticle

Sica, G, Fabbroni, L, Dell’Acqua, G, Iacopino, F, Marchetti, P, Cacciatore, M & Pavone-Macaluso, M 1991, 'Natural β-interferon and androgen receptors inprostatic cancer cells', Urologia Internationalis, vol. 46, no. 2, pp. 159-162. https://doi.org/10.1159/000282123
Sica G, Fabbroni L, Dell’Acqua G, Iacopino F, Marchetti P, Cacciatore M et al. Natural β-interferon and androgen receptors inprostatic cancer cells. Urologia Internationalis. 1991;46(2):159-162. https://doi.org/10.1159/000282123
Sica, Gigliola ; Fabbroni, L. ; Dell’Acqua, G. ; Iacopino, F. ; Marchetti, P. ; Cacciatore, M. ; Pavone-Macaluso, M. / Natural β-interferon and androgen receptors inprostatic cancer cells. In: Urologia Internationalis. 1991 ; Vol. 46, No. 2. pp. 159-162.
@article{49d3fe5727df47dfa27ea2570bdc32e8,
title = "Natural β-interferon and androgen receptors inprostatic cancer cells",
abstract = "Both PC-3 and DU-145 cell lines are androgen-insensitive, but, in our experience, they contain androgen receptors (AR). Treatment of these cells with natural β-interferon at aconcentration of 1, 000 IU/ml of culture medium determines an increase of AR (evaluated by a whole-cell assay), statistically significant with respect to control. Androgen unresponsiveness of our cells could be due to an AR level which is lower than that present in hormone-sensitive prostatic cancer cell lines, such as LNCaP cells. For this reason, interferon-promoted AR increase merits further investigation, even if other defects in receptor mechanism, responsible for hormone insensitivity, cannot be excluded.",
keywords = "Androgen receptors, Prostatic cancer cells, β-Interferon",
author = "Gigliola Sica and L. Fabbroni and G. Dell’Acqua and F. Iacopino and P. Marchetti and M. Cacciatore and M. Pavone-Macaluso",
year = "1991",
doi = "10.1159/000282123",
language = "English",
volume = "46",
pages = "159--162",
journal = "Urologia Internationalis",
issn = "0042-1138",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Natural β-interferon and androgen receptors inprostatic cancer cells

AU - Sica, Gigliola

AU - Fabbroni, L.

AU - Dell’Acqua, G.

AU - Iacopino, F.

AU - Marchetti, P.

AU - Cacciatore, M.

AU - Pavone-Macaluso, M.

PY - 1991

Y1 - 1991

N2 - Both PC-3 and DU-145 cell lines are androgen-insensitive, but, in our experience, they contain androgen receptors (AR). Treatment of these cells with natural β-interferon at aconcentration of 1, 000 IU/ml of culture medium determines an increase of AR (evaluated by a whole-cell assay), statistically significant with respect to control. Androgen unresponsiveness of our cells could be due to an AR level which is lower than that present in hormone-sensitive prostatic cancer cell lines, such as LNCaP cells. For this reason, interferon-promoted AR increase merits further investigation, even if other defects in receptor mechanism, responsible for hormone insensitivity, cannot be excluded.

AB - Both PC-3 and DU-145 cell lines are androgen-insensitive, but, in our experience, they contain androgen receptors (AR). Treatment of these cells with natural β-interferon at aconcentration of 1, 000 IU/ml of culture medium determines an increase of AR (evaluated by a whole-cell assay), statistically significant with respect to control. Androgen unresponsiveness of our cells could be due to an AR level which is lower than that present in hormone-sensitive prostatic cancer cell lines, such as LNCaP cells. For this reason, interferon-promoted AR increase merits further investigation, even if other defects in receptor mechanism, responsible for hormone insensitivity, cannot be excluded.

KW - Androgen receptors

KW - Prostatic cancer cells

KW - β-Interferon

UR - http://www.scopus.com/inward/record.url?scp=0025829541&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025829541&partnerID=8YFLogxK

U2 - 10.1159/000282123

DO - 10.1159/000282123

M3 - Article

VL - 46

SP - 159

EP - 162

JO - Urologia Internationalis

JF - Urologia Internationalis

SN - 0042-1138

IS - 2

ER -