TY - JOUR
T1 - Natural and synthetic retinoids
T2 - Structural bases and biological effects of potential clinical relevance for the prevention and treatment of infection-driven tumors
AU - Dolcetti, Riccardo
AU - Di Luca, Dario
AU - de Lera, Angel R.
PY - 2006/1
Y1 - 2006/1
N2 - Retinoids play a critical role in the regulation of cell division, growth, differentiation, and proliferation, and represent an exciting new avenue for targeted therapy of different diseases, including cancer. Natural and synthetic retinoids are also endowed with antiviral properties that make these compounds particularly attractive for the prevention and treatment of infection-driven tumors. In this review, we will summarize the structural bases and the cellular and antiviral effects of retinoids which provide a molecular basis for the management of virus-associated tumors, including Kaposi's sarcoma (HHV-8) and post-transplant lymphoproliferative disorders (EBV). Particular relevance will be given to the selectivity of these retinoids for their cognate receptors (RAR and RXR) in order to establish a link between receptor modulation and antiviral/antitumor effects.
AB - Retinoids play a critical role in the regulation of cell division, growth, differentiation, and proliferation, and represent an exciting new avenue for targeted therapy of different diseases, including cancer. Natural and synthetic retinoids are also endowed with antiviral properties that make these compounds particularly attractive for the prevention and treatment of infection-driven tumors. In this review, we will summarize the structural bases and the cellular and antiviral effects of retinoids which provide a molecular basis for the management of virus-associated tumors, including Kaposi's sarcoma (HHV-8) and post-transplant lymphoproliferative disorders (EBV). Particular relevance will be given to the selectivity of these retinoids for their cognate receptors (RAR and RXR) in order to establish a link between receptor modulation and antiviral/antitumor effects.
KW - Epstein-barr virus
KW - Human herpesvirus 8
KW - Human immunodeficiency virus
KW - RARs
KW - Retinoids
KW - Rexinoids
KW - RXRs
UR - http://www.scopus.com/inward/record.url?scp=33744492074&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33744492074&partnerID=8YFLogxK
U2 - 10.2174/187152106774755617
DO - 10.2174/187152106774755617
M3 - Article
AN - SCOPUS:33744492074
VL - 5
SP - 85
EP - 103
JO - Current Medicinal Chemistry: Immunology, Endocrine and Metabolic Agents
JF - Current Medicinal Chemistry: Immunology, Endocrine and Metabolic Agents
SN - 1871-5222
IS - 1
ER -