Natural anti-endothelial cell antibodies (AECA)

N. Ronda, S. Leonardi, G. Orlandini, R. Gatti, S. Bellosta, F. Bernini, A. Borghetti

Research output: Contribution to journalArticlepeer-review


Natural AECA constitute a pool of autoantibodies circulating in healthy subjects, which react with a restricted and conserved set of endothelial antigens and establish idiotypic interactions within the immunoglobulin networks. Normal IgG interacts with living endothelial cells and is internalized with a mechanism involving microtubules and resembling that of ligand-receptor internalization. IgG-endothelial cell interaction appears to be dependent on the variable region of antibodies and is followed by modifications of endothelial cell function. Natural AECA increase anti- inflammatory properties of endothelial cells through the selective inhibition of thromboxane A2, endothelin and metalloproteinase-9 secretion, and also through the inhibition of endothelial cell proinflammatory response to TNF- α. We have gathered evidence demonstrating that natural AECA constitute a strictly controlled autoantibody pool, interact with living endothelial cells and take part in the regulation of endothelial function, through direct antiinflammatory effects.

Original languageEnglish
Pages (from-to)121-127
Number of pages7
JournalJournal of Autoimmunity
Issue number1
Publication statusPublished - 1999


  • Autoantibodies
  • Endocytosis
  • Endothelial cell
  • Function
  • Immunoglobulin G

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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