Natural compounds against neurodegenerative diseases: molecular characterization of the interaction of catechins from green tea with Aβ1-42, PrP106-126, and ataxin-3 oligomers

Erika Sironi, Laura Colombo, Angela Lompo, Massimo Messa, Marcella Bonanomi, Maria E lena Regonesi, Mario Salmona, Cristina Airoldi

Research output: Contribution to journalArticlepeer-review

Abstract

By combining NMR spectroscopy, transmission electron microscopy, and circular dichroism we have identified the structural determinants involved in the interaction of green tea catechins with Aβ1-42, PrP106-126, and ataxin-3 oligomers. The data allow the elucidation of their mechanism of action, showing that the flavan-3-ol unit of catechins is essential for interaction. At the same time, the gallate moiety, when present, seems to increase the affinity for the target proteins. These results provide important information for the rational design of new compounds with anti-amyloidogenic activity and/or molecular tools for the specific targeting of amyloid aggregates in vivo.

Original languageEnglish
Pages (from-to)13793-13800
Number of pages8
JournalChemistry - A European Journal
Volume20
Issue number42
DOIs
Publication statusPublished - Oct 13 2014

Keywords

  • amyloid peptides
  • circular dichroism
  • molecular recognition
  • NMR spectroscopy
  • structure-activity relationship

ASJC Scopus subject areas

  • Medicine(all)

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