Natural Compounds and Their Derivatives as Multifunctional Agents for the Treatment of Alzheimer Disease

Rosa Tundis; Monica R. Loizzo; Seyed M. Nabavi; Ilkay Erdogan Orhan; Krystyna Skalicka-Wozniak; Grazia D'Onofrio; Francesca Aiello

doi:10.1016/B978-0-12-809593-5.00003-3

Natural Compounds and Their Derivatives as Multifunctional Agents for the Treatment of Alzheimer Disease

Rosa Tundis, Monica R. Loizzo, Seyed M. Nabavi, Ilkay Erdogan Orhan, Krystyna Skalicka-Wozniak, Grazia D'Onofrio, Francesca Aiello

IRCCS Casa Sollievo della Sofferenza

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Alzheimer disease (AD) is a complex and progressive neurodegenerative disease. AD is one of the greatest challenges to modern medicine because multiple pathogenetic factors are associated with this disease. The current pharmacologic treatment offers limited symptomatic benefits. Due to the multifactorial etiology, dedicated search for new molecules that can aim at multiple targets, including cholinesterase inhibition, amyloid-β antiaggregation activity, β-secretase and monoamine oxidase inhibition, nitric oxide releasing ability and interaction with cannabinoid (CB1, CB2), and N-methyl- d-aspartate or histamine H3 receptors, is an attractive prospect for the development of new anti-AD drugs. Considering that the presently approved drugs for the treatment of AD are mainly based on natural products, the search for natural products as anti-AD drugs has been considerably developed in the past two decades. This chapter is focused on natural compounds and their derivatives as potential multifunctional anti-AD agents. Among the reported phytochemicals and their derivatives, a good numbers of compounds seem to be promising candidates in the search for new therapies for AD.

Original language	English
Title of host publication	Discovery and Development of Neuroprotective Agents from Natural Products
Subtitle of host publication	Natural Product Drug Discovery
Publisher	Elsevier
Pages	63-102
Number of pages	40
ISBN (Electronic)	9780128097694
ISBN (Print)	9780128095935
DOIs	https://doi.org/10.1016/B978-0-12-809593-5.00003-3
Publication status	Published - Jun 8 2017

Keywords

Alzheimer disease
Medicinal plants
Multifunctional agents
Natural compounds

ASJC Scopus subject areas

Chemistry(all)

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Tundis, R., Loizzo, M. R., Nabavi, S. M., Orhan, I. E., Skalicka-Wozniak, K., D'Onofrio, G., & Aiello, F. (2017). Natural Compounds and Their Derivatives as Multifunctional Agents for the Treatment of Alzheimer Disease. In Discovery and Development of Neuroprotective Agents from Natural Products: Natural Product Drug Discovery (pp. 63-102). Elsevier. https://doi.org/10.1016/B978-0-12-809593-5.00003-3

Natural Compounds and Their Derivatives as Multifunctional Agents for the Treatment of Alzheimer Disease. / Tundis, Rosa; Loizzo, Monica R.; Nabavi, Seyed M.; Orhan, Ilkay Erdogan; Skalicka-Wozniak, Krystyna; D'Onofrio, Grazia; Aiello, Francesca.

Discovery and Development of Neuroprotective Agents from Natural Products: Natural Product Drug Discovery. Elsevier, 2017. p. 63-102.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Tundis, R, Loizzo, MR, Nabavi, SM, Orhan, IE, Skalicka-Wozniak, K, D'Onofrio, G & Aiello, F 2017, Natural Compounds and Their Derivatives as Multifunctional Agents for the Treatment of Alzheimer Disease. in Discovery and Development of Neuroprotective Agents from Natural Products: Natural Product Drug Discovery. Elsevier, pp. 63-102. https://doi.org/10.1016/B978-0-12-809593-5.00003-3

Tundis R, Loizzo MR, Nabavi SM, Orhan IE, Skalicka-Wozniak K, D'Onofrio G et al. Natural Compounds and Their Derivatives as Multifunctional Agents for the Treatment of Alzheimer Disease. In Discovery and Development of Neuroprotective Agents from Natural Products: Natural Product Drug Discovery. Elsevier. 2017. p. 63-102 https://doi.org/10.1016/B978-0-12-809593-5.00003-3

Tundis, Rosa ; Loizzo, Monica R. ; Nabavi, Seyed M. ; Orhan, Ilkay Erdogan ; Skalicka-Wozniak, Krystyna ; D'Onofrio, Grazia ; Aiello, Francesca. / Natural Compounds and Their Derivatives as Multifunctional Agents for the Treatment of Alzheimer Disease. Discovery and Development of Neuroprotective Agents from Natural Products: Natural Product Drug Discovery. Elsevier, 2017. pp. 63-102

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