Natural course of HCV infection in childhood cancer survivors

Francesca Fioredda, Andrea Moser, Luisella Bertoluzzo, Herwig Lackner, Raffaella Giacchino, Milena LaSpina, Luisella Lazier, Caterina Riva, Mareva Giacchino, Donatella Fraschini, Eva Frey, Angela Sementa, Angela Pistorio, Riccardo Haupt

Research output: Contribution to journalArticle

Abstract

Goals of work To describe the course of hepatitis C in a cohort of 105 survivors after childhood cancer. Patients and methods Data on chemo/radiotherapy, clinical status, serial alanine aminotransferase (ALT) evaluation, and virological parameters after the end of treatment were collected for each patient. Liver biopsies, when performed, were centrally evaluated by a pathologist. Main results All patients were alive at the end of follow-up and did not show hepatic insufficiency. ALT evaluation along the entire follow-up showed a moderate (87%) or a remarkable (13%) cytolytic pattern. Young age at diagnosis, hematopoietic stem cell transplantation, and duration of infection significantly correlate with a worse hepatic activity. Type of tumor and chemo and/or radiotherapy regimens did not influence the pattern of hepatic cytolysis. Liver biopsy, centrally reviewed in 30% of the cohort, showed one case of cirrhosis and mild fibrosis in 71% of the group. Higher degrees of fibrosis did not seemto be related to any exposition to chemo/radiotherapy but correlated significantly with the more remarkable cytolytic course. Conclusions The outcome of hepatitis C in our patients is comparable to the one described in European cohorts of adult cancer survivors and perinatally infected subjects. Nevertheless, progression to high degrees of hepatic damage has to be monitored by a careful follow-up.

Original languageEnglish
Pages (from-to)1413-1420
Number of pages8
JournalSupportive Care in Cancer
Volume18
Issue number11
DOIs
Publication statusPublished - Nov 2010

Keywords

  • Chronic hepatitis C
  • HCVafter cancer
  • Long-term survivors

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology

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  • Cite this

    Fioredda, F., Moser, A., Bertoluzzo, L., Lackner, H., Giacchino, R., LaSpina, M., Lazier, L., Riva, C., Giacchino, M., Fraschini, D., Frey, E., Sementa, A., Pistorio, A., & Haupt, R. (2010). Natural course of HCV infection in childhood cancer survivors. Supportive Care in Cancer, 18(11), 1413-1420. https://doi.org/10.1007/s00520-009-0763-7