Natural cycle as first approach in aged patients with elevated follicle-stimulating hormone undergoing intracytoplasmic sperm injection: A pilot study

Enrico Papaleo, Lucia De Santis, Francesco Fusi, Nicola Doldi, Claudio Brigante, Guido Marelli, Paola Persico, Ilaria Cino, Augusto Ferrari

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Poor ovarian response to standard in vitro fertilization-embryo transfer (IVF-ET) protocols or different regimens of treatment, as consequence of a diminished ovarian reserve, correlates strictly with patient age, elevated follicle-stimulating hormone (FSH) and reduced antral follicle count. The aim of the present pilot study was to evaluate the outcome of patients with poor prognostic features undergoing IVF-ET with natural cycles as a first approach and not as a consequence of a previous failure treatment. Materials and methods. Eighteen aged patients (mean ± standard deviation 40.2 ± 0.7 years, range 37-43 years) with elevated serum FSH and reduced antral follicle count underwent intracytoplasmic sperm injection (ICSI) after spontaneous ovulation. Results. A total of 26 natural cycles with ICSI were analyzed. Pregnancy was observed in three patients, of which two were ongoing as assessed by fetal heart beat at ultrasound scan performed 4-5 weeks after ET. Conclusion. The overall pregnancy rates achieved (11.5% per cycle, 20.0% per ET) are comparable with those of conventional IVF-ET in aged patients, and not impaired by a single embryo transferred. Better embryo quality, as a consequence of natural selection of oocytes, better endometrium receptivity and monthly repeatability of the procedure, can balance the relatively low chance to perform ET.

Original languageEnglish
Pages (from-to)351-354
Number of pages4
JournalGynecological Endocrinology
Volume22
Issue number7
DOIs
Publication statusPublished - Jul 1 2006

Keywords

  • Aged patients
  • Elevated follicle-stimulating hormone
  • Intracytoplasmic sperm injection
  • Natural cycle

ASJC Scopus subject areas

  • Endocrinology
  • Obstetrics and Gynaecology

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