Natural endocannabinoid derivatives as templates for the development of FAAH inhibitors

Enrico Dainese, Mauro Maccarrone

Research output: Contribution to journalArticle

Abstract

The endogenous cannabinoids (endocannabinoids) are amides, esters and ethers of long chain polyunsaturated fatty acids. These lipids are bioactive signaling molecules that show diverse cellular and physiological effects and play various roles both in the central nervous system and in the periphery. The discovery of N-arachidonoylethanolamine (anandamide, AEA) and of the enzyme that terminates its signaling, i.e. fatty acid amide hydrolase (FAAH), have inspired pharmacological strategies to augment endocannabinoid tone and biological activity through inhibition of FAAH. Here we discuss the role of natural endocannabinoid derivatives, like the hydroxy-anandamides (OH-AEAs) generated from AEA via lipoxygenase activity, as powerful inhibitors of FAAH. We propose that these compounds, by reversibly inhibiting FAAH, may control in vivo the endocannabinoid tone. We discuss also the potential value of OH-AEAs as templates for the development of next-generation therapeutics that act at specific sites of FAAH.

Original languageEnglish
Pages (from-to)372-376
Number of pages5
JournalLetters in Drug Design and Discovery
Volume2
Issue number5
DOIs
Publication statusPublished - Aug 2005

Keywords

  • Anandamide hydrolase
  • Endocannabinoids
  • Inhibition
  • Lipoxygenase
  • Nervous system
  • Therapy

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Pharmaceutical Science

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