Natural evolution of skin-test sensitivity in patients with IgE-mediated hypersensitivity to cephalosporins

A. Romano, F. Gaeta, R. L. Valluzzi, A. Zaffiro, C. Caruso, D. Quaratino

Research output: Contribution to journalArticlepeer-review

Abstract

There are studies demonstrating that skin-test sensitivity to penicillins can decrease over time and that allergic patients may lose sensitivity if the responsible compounds are avoided. With regard to subjects with IgE-mediated hypersensitivity to cephalosporins, however, such studies are lacking. We evaluated prospectively in a 5-year follow-up 72 cephalosporin-allergic patients. After the first evaluation, patients were classified into two groups according to their patterns of allergologic-test positivity: to both penicillins and cephalosporins (group A), or only to cephalosporins (group B). Skin tests and serum-specific IgE assays were repeated 1 year later and, in case of persistent positivity, 3 and 5 years after the first allergologic examination. Seven (43.7%) of the 16 subjects of group A and 38 (67.8%) of the 56 patients of group B became negative; one was lost to follow-up. Patients of group B became negative sooner and more frequently than group A subjects.

Original languageEnglish
Pages (from-to)806-809
Number of pages4
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume69
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • cephalosporin allergy
  • follow-up
  • skin tests

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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