TY - JOUR
T1 - Natural extracellular nanovesicles and photodynamic molecules
T2 - is there a future for drug delivery?
AU - Kusuzaki, Katsuyuki
AU - Matsubara, Takao
AU - Murata, Hiroaki
AU - Logozzi, Mariantonia
AU - Iessi, Elisabetta
AU - Di Raimo, Rossella
AU - Carta, Fabrizio
AU - Supuran, Claudiu T.
AU - Fais, Stefano
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Photodynamic molecules represent an alternative approach for cancer therapy for their property (i) to be photo-reactive; (ii) to be not-toxic for target cells in absence of light; (iii) to accumulate specifically into tumour tissues; (iv) to be activable by a light beam only at the tumour site and (v) to exert cytotoxic activity against tumour cells. However, to date their clinical use is limited by the side effects elicited by systemic administration. Extracellular vesicles are endogenous nanosized-carriers that have been recently introduced as a natural delivery system for therapeutic molecules. We have recently shown the ability of human exosomes to deliver photodynamic molecules. Therefore, this review focussed on extracellular vesicles as a novel strategy for the delivery of photodynamic molecules at cancer sites. This completely new approach may enhance the delivery and decrease the toxicity of photodynamic molecules, therefore, represent the future for photodynamic therapy for cancer treatment.
AB - Photodynamic molecules represent an alternative approach for cancer therapy for their property (i) to be photo-reactive; (ii) to be not-toxic for target cells in absence of light; (iii) to accumulate specifically into tumour tissues; (iv) to be activable by a light beam only at the tumour site and (v) to exert cytotoxic activity against tumour cells. However, to date their clinical use is limited by the side effects elicited by systemic administration. Extracellular vesicles are endogenous nanosized-carriers that have been recently introduced as a natural delivery system for therapeutic molecules. We have recently shown the ability of human exosomes to deliver photodynamic molecules. Therefore, this review focussed on extracellular vesicles as a novel strategy for the delivery of photodynamic molecules at cancer sites. This completely new approach may enhance the delivery and decrease the toxicity of photodynamic molecules, therefore, represent the future for photodynamic therapy for cancer treatment.
KW - acridine orange
KW - exosomes
KW - Extracellular nanovesicles
KW - photodynamic molecules
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U2 - 10.1080/14756366.2017.1335310
DO - 10.1080/14756366.2017.1335310
M3 - Review article
C2 - 28708430
AN - SCOPUS:85023761281
VL - 32
SP - 908
EP - 916
JO - Journal of Enzyme Inhibition and Medicinal Chemistry
JF - Journal of Enzyme Inhibition and Medicinal Chemistry
SN - 1475-6366
IS - 1
ER -