Natural history of cardiac involvement in myotonic dystrophy: Correlation with CTG repeats

Giovanni Antonini, F. Giubilei, A. Mammarella, P. Amicucci, M. Fiorelli, F. Gragnani, S. Morino, V. Ceschin, P. V. Fragola, M. Gennarelli

Research output: Contribution to journalArticlepeer-review

Abstract

The authors prospectively studied the natural course of cardiac involvement and its relationship to cytosine-thymine-guanine (CTG) expansion in 50 patients with myotonic dystrophy who were submitted to periodic cardiovascular EKG and EKG-Holter monitoring during a median follow-up of 56 months. Nineteen patients (38%) developed major EKG changes. CTG length was not correlated with the frequency of EKG abnormalities, but was inversely correlated with the age at onset of EKG abnormalities (p <0.0001). CTG length influences the timing of cardiac complications in myotonic dystrophy.

Original languageEnglish
Pages (from-to)1207-1209
Number of pages3
JournalNeurology
Volume55
Issue number8
Publication statusPublished - Oct 24 2000

ASJC Scopus subject areas

  • Neuroscience(all)

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