Abstract
The authors prospectively studied the natural course of cardiac involvement and its relationship to cytosine-thymine-guanine (CTG) expansion in 50 patients with myotonic dystrophy who were submitted to periodic cardiovascular EKG and EKG-Holter monitoring during a median follow-up of 56 months. Nineteen patients (38%) developed major EKG changes. CTG length was not correlated with the frequency of EKG abnormalities, but was inversely correlated with the age at onset of EKG abnormalities (p <0.0001). CTG length influences the timing of cardiac complications in myotonic dystrophy.
Original language | English |
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Pages (from-to) | 1207-1209 |
Number of pages | 3 |
Journal | Neurology |
Volume | 55 |
Issue number | 8 |
Publication status | Published - Oct 24 2000 |
ASJC Scopus subject areas
- Neuroscience(all)