Natural history of cardiac involvement in myotonic dystrophy: Correlation with CTG repeats

Giovanni Antonini; F. Giubilei; A. Mammarella; P. Amicucci; M. Fiorelli; F. Gragnani; S. Morino; V. Ceschin; P. V. Fragola; M. Gennarelli

Natural history of cardiac involvement in myotonic dystrophy: Correlation with CTG repeats

Giovanni Antonini, F. Giubilei, A. Mammarella, P. Amicucci, M. Fiorelli, F. Gragnani, S. Morino, V. Ceschin, P. V. Fragola, M. Gennarelli

Centro San Giovanni di Dio - Fatebenefratelli

Research output: Contribution to journal › Article › peer-review

Abstract

The authors prospectively studied the natural course of cardiac involvement and its relationship to cytosine-thymine-guanine (CTG) expansion in 50 patients with myotonic dystrophy who were submitted to periodic cardiovascular EKG and EKG-Holter monitoring during a median follow-up of 56 months. Nineteen patients (38%) developed major EKG changes. CTG length was not correlated with the frequency of EKG abnormalities, but was inversely correlated with the age at onset of EKG abnormalities (p <0.0001). CTG length influences the timing of cardiac complications in myotonic dystrophy.

Original language	English
Pages (from-to)	1207-1209
Number of pages	3
Journal	Neurology
Volume	55
Issue number	8
Publication status	Published - Oct 24 2000

ASJC Scopus subject areas

Neuroscience(all)

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abstract = "The authors prospectively studied the natural course of cardiac involvement and its relationship to cytosine-thymine-guanine (CTG) expansion in 50 patients with myotonic dystrophy who were submitted to periodic cardiovascular EKG and EKG-Holter monitoring during a median follow-up of 56 months. Nineteen patients (38%) developed major EKG changes. CTG length was not correlated with the frequency of EKG abnormalities, but was inversely correlated with the age at onset of EKG abnormalities (p <0.0001). CTG length influences the timing of cardiac complications in myotonic dystrophy.",

author = "Giovanni Antonini and F. Giubilei and A. Mammarella and P. Amicucci and M. Fiorelli and F. Gragnani and S. Morino and V. Ceschin and Fragola, {P. V.} and M. Gennarelli",

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T2 - Correlation with CTG repeats

AU - Antonini, Giovanni

AU - Giubilei, F.

AU - Mammarella, A.

AU - Amicucci, P.

AU - Fiorelli, M.

AU - Gragnani, F.

AU - Morino, S.

AU - Ceschin, V.

AU - Fragola, P. V.

AU - Gennarelli, M.

PY - 2000/10/24

Y1 - 2000/10/24

N2 - The authors prospectively studied the natural course of cardiac involvement and its relationship to cytosine-thymine-guanine (CTG) expansion in 50 patients with myotonic dystrophy who were submitted to periodic cardiovascular EKG and EKG-Holter monitoring during a median follow-up of 56 months. Nineteen patients (38%) developed major EKG changes. CTG length was not correlated with the frequency of EKG abnormalities, but was inversely correlated with the age at onset of EKG abnormalities (p <0.0001). CTG length influences the timing of cardiac complications in myotonic dystrophy.

AB - The authors prospectively studied the natural course of cardiac involvement and its relationship to cytosine-thymine-guanine (CTG) expansion in 50 patients with myotonic dystrophy who were submitted to periodic cardiovascular EKG and EKG-Holter monitoring during a median follow-up of 56 months. Nineteen patients (38%) developed major EKG changes. CTG length was not correlated with the frequency of EKG abnormalities, but was inversely correlated with the age at onset of EKG abnormalities (p <0.0001). CTG length influences the timing of cardiac complications in myotonic dystrophy.

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