Natural history of charcot-marie-tooth 2: 2-year follow-up of muscle strength, walking ability and quality of life

Luca Padua, D. Pareyson, I. Aprile, T. Cavallaro, D. A. Quattrone, N. Rizzuto, G. Vita, P. Tonali, A. Schenone

Research output: Contribution to journalArticlepeer-review

Abstract

Charcot-Marie-Tooth (CMT) disease is the most frequent inherited neuropathy, no therapies are available at the moment but clinical trials are ongoing. For that reason it is very important to know the natural history of the disease. We report the results of the natural history of clinical features and quality of life (QoL) in patients with CMT2. Twenty patients were enrolled. At recruitment and at follow-up (2 years), all patients underwent neurological evaluation, QoL and disability assessments. The study-end evaluation took place 20-28 months after the baseline evaluation. During the 2-year follow-up period, CMT2 patients showed a mild reduction of strength of distal muscles of upper limbs and proximal muscles of lower limbs, a worsening sensory function and a mild increase in walking disability. However, there was no relevant worsening of QoL, except for a mild deterioration of one mental health domain.

Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalNeurological Sciences
Volume31
Issue number2
DOIs
Publication statusPublished - Apr 2010

Keywords

  • Charcot-marie-tooth
  • Neurological evaluation
  • Quality of life

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

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