Natural history of congestive gastropathy in cirrhosis

Gennaro D'Amico, Luigi Montalbano, Mario Traina, Roberto Pisa, Mario Menozzi, Caterina Spanò, Luigi Pagliaro

Research output: Contribution to journalArticle

Abstract

In a prospective study of the natural history of congestive gastropathy, 212 consecutive cirrhotic patients (75 treated with sclerotherapy) were included. Mean follow-up was 46 months. Mild gastropathy (mosaiclike pattern) was found in 110 patients and severe gastropathy (granular mucosa with cherry spots) was found in 20. Prevalence of Helicobacter pylori, formerly Campylobacter pylori, was 50% in patients without, 43% in those with mild, and 28% in those with severe gastropathy. Congestive gastropathy was significantly more frequent in patients treated with sclerotherapy (83% vs. 50%, P <10-5). Sixtymonth actuarial proportions of patients free of anemia (in the absence of hematemesis or melena), were 17% with severe, 62% with mild, and 93% without gastropathy (P <10-8). Corresponding figures for overt bleeding were 25%, 73%, and 87% (P <10-7), whereas those for survival were 46%, 72%, and 85% (P = 0.0005), respectively. A multivariate regression analysis supported the following conclusions: (a) sclerotherapy and the presence of large esophageal varices significantly increase the risk of congestive gastropathy, which (b) is a significant risk indicator of both chronic and overt bleeding but does not independently affect survival.

Original languageEnglish
Pages (from-to)1558-1564
Number of pages7
JournalGastroenterology
Volume99
Issue number6
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Gastroenterology

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    D'Amico, G., Montalbano, L., Traina, M., Pisa, R., Menozzi, M., Spanò, C., & Pagliaro, L. (1990). Natural history of congestive gastropathy in cirrhosis. Gastroenterology, 99(6), 1558-1564.