Natural history of gastro-entero-pancreatic and thoracic neuroendocrine tumors. Data froma large prospective and retrospective Italian Epidemiological study: The net management study

A. Faggiano, P. Ferolla, F. Grimaldi, D. Campana, M. Manzoni, M. V. Davì, A. Bianchi, R. Valcavi, E. Papini, D. Giuffrida, D. Ferone, G. Fanciulli, G. Arnaldi, G. M. Franchi, G. Francia, G. Fasola, L. Crinò, A. Pontecorvi, P. Tomassetti, A. Colao

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The few epidemiological data available in literature on neuroendocrine tumors (NET) are mainly based on Registry databases, missing therefore details on their clinical and natural history. Aim: To investigate epidemiology, clinical presentation, and natural history of NET. Design and setting: A large national retrospective survey was conducted in 13 Italian referral centers. Among 1203 NET, 820 originating in the thorax (T-NET), in the gastro-enteropancreatic tract (GEP-NET) or metastatic NET of unknown primary origin (U-NET) were enrolled in the study. Results: 93% had a sporadic and 7% a multiple endocrine neoplasia type 1 (MEN1)-associated tumor; 63% were GEP-NET, 33% T-NET, 4% U-NET. Pancreas and lung were the commonest primary sites. Poorly differentiated carcinomas were

Original languageEnglish
Pages (from-to)817-823
Number of pages7
JournalJournal of Endocrinological Investigation
Volume35
Issue number9
DOIs
Publication statusPublished - Oct 2012

Keywords

  • Carcinoid
  • Clinical presentation
  • Epidemiology
  • Natural history
  • Neuroendocrine tumor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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