Natural History of Leber's Hereditary Optic Neuropathy: Longitudinal Analysis of the Retinal Nerve Fiber Layer by Optical Coherence Tomography

Piero Barboni, Michele Carbonelli, Giacomo Savini, Carolina do V F Ramos, Arturo Carta, Adriana Berezovsky, Solange R. Salomao, Valerio Carelli, Alfredo A. Sadun

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Purpose: To investigate by optical coherence tomography (OCT) the topographic pattern and temporal sequence of fiber loss in the peripapillary retinal nerve fiber layer (RNFL) of patients with Leber's hereditary optic neuropathy (LHON) in a longitudinal follow-up. Design: Cohort study. Participants: Six eyes of 4 patients with molecularly defined LHON were enrolled before the subacute period of visual loss. Methods: Subjects were studied by StratusOCT (Carl Zeiss Meditec, Inc., Dublin, CA) during a 9-month follow-up starting from the presymptomatic stage of the disease. Examinations were carried out at 4 different time points: presymptomatic stage, time of visual loss, and 3 and 9 months later. Main Outcome Measures: Peripapillary RNFL thickness for each quadrant of the optic nerve. Statistical comparisons were performed by ordinary analysis of variance with Dunnett's post-test. Results: A significant increase of RNFL thickness was detected in the temporal and inferior quadrants between the presymptomatic stage and the disease onset (P

Original languageEnglish
Pages (from-to)623-627
Number of pages5
JournalOphthalmology
Volume117
Issue number3
DOIs
Publication statusPublished - Mar 2010

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Leber's Hereditary Optic Atrophy
Optical Coherence Tomography
Nerve Fibers
Asymptomatic Diseases
Optic Nerve
Analysis of Variance
Cohort Studies
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Ophthalmology

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Natural History of Leber's Hereditary Optic Neuropathy : Longitudinal Analysis of the Retinal Nerve Fiber Layer by Optical Coherence Tomography. / Barboni, Piero; Carbonelli, Michele; Savini, Giacomo; Ramos, Carolina do V F; Carta, Arturo; Berezovsky, Adriana; Salomao, Solange R.; Carelli, Valerio; Sadun, Alfredo A.

In: Ophthalmology, Vol. 117, No. 3, 03.2010, p. 623-627.

Research output: Contribution to journalArticle

Barboni, Piero ; Carbonelli, Michele ; Savini, Giacomo ; Ramos, Carolina do V F ; Carta, Arturo ; Berezovsky, Adriana ; Salomao, Solange R. ; Carelli, Valerio ; Sadun, Alfredo A. / Natural History of Leber's Hereditary Optic Neuropathy : Longitudinal Analysis of the Retinal Nerve Fiber Layer by Optical Coherence Tomography. In: Ophthalmology. 2010 ; Vol. 117, No. 3. pp. 623-627.
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