Natural killer activity and antibody-dependent cellular cytotoxicity in progressive systemic sclerosis

M. G. Cifone, R. Giacomelli, G. Famularo, R. Paolini, C. Danese, T. Napolitano, A. Procopio, A. M. Perego, A. Santoni, G. Tonietti

Research output: Contribution to journalArticlepeer-review

Abstract

Enhanced natural killer (NK) activity and normal lymphocyte antibody-dependent cellular cytotoxicity (ADCC) were observed in 16 patients with a diagnosis of progressive systemic sclerosis (PSS). Higher NK activity levels were observed against NK-sensitive K562 target cells, while the NK-resistant P815, Daudi and Raji cell lines were not lysed. Cytofluorimetric studies and morphological analysis of peripheral blood lymphocytes (PBL) showed an increased number of CD16 positive cells and large granular lymphocytes (LGL), indicating that the enhancement observed was probably attributable to an increase in the number of circulating NK cells.

Original languageEnglish
Pages (from-to)360-365
Number of pages6
JournalClinical and Experimental Immunology
Volume80
Issue number3
Publication statusPublished - 1990

Keywords

  • ADCC
  • large granular lymphocytes
  • NK activity
  • progressive systemic sclerosis

ASJC Scopus subject areas

  • Immunology

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