Natural killer activity in patients with acute viral hepatitis

L. Chemello, M. Mondelli, F. Bortolotti, E. Schiavon, P. Pontisso, A. Alberti, E. G. Rondanelli, G. Realdi

Research output: Contribution to journalArticlepeer-review

Abstract

Using the natural killer (NK) sensitive K562 cell line, enhanced NK cell cytotoxicity was demonstrable early in the course of acute hepatitis B while normal values were obtained in patients studied during convalescence. No evidence of enhanced NK activity was instead obtained in the course of acute non-A, non-B hepatitis. Serum levels of α-interferon, as determined by radioimmunoassay (RIA), were significantly increased in patients with acute hepatitis B showing enhanced NK cell activity but not in those with acute non-A, non-B hepatitis and normal NK cell activity. These results suggest that natural cytotoxicity may play a role early in the course of acute hepatitis type B, before antigen-specific T lymphocytes become fully operative.

Original languageEnglish
Pages (from-to)59-64
Number of pages6
JournalClinical and Experimental Immunology
Volume64
Issue number1
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Immunology

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