Natural killer activity in spleens and lymph nodes from patients with Hodgkin's disease

L. P. Ruco, A. Procopio, S. Uccini, E. Marcorelli, C. D. Baroni

Research output: Contribution to journalArticle

Abstract

Natural killer (NK) activity against K-562 myeloid cell line was evaluated in 21 spleens and 14 lymph nodes from patients with Hodgkin's disease (HD). NK activity of eight HD-involved (HD+) spleens [556 lytic units (LU)] was found 5-fold higher than that of 13 HD-uninvolved (HD-) spleens (112 LU) (p+ spleens was significantly different (p+ and HD- spleens. Lymph node cells were about 10-fold less cytotoxic. NK activity of seven HD+ lymph nodes (43 LU) was 3-fold higher than that of three lymph nodes involved by non-HD lymphoma (8 LU). However, these differences were not statistically significant. Our data are compatible with increased NK activity in HD+ tissues as well as with depressed NK activity in HD- tissues. The observation that NK activity of peripheral blood leukocytes from nine HD patients (116 LU) (p+ and in HD- spleens indicated that, in both instances, NK cells were nonadherent and almost equally distributed between the erythrocyte-negative and -positive cell fractions. Finally, NK activity of both HD+ and HD- spleen cells could be further potentiated in vitro by interferon.

Original languageEnglish
Pages (from-to)2063-2068
Number of pages6
JournalCancer Research
Volume42
Issue number5
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Ruco, L. P., Procopio, A., Uccini, S., Marcorelli, E., & Baroni, C. D. (1982). Natural killer activity in spleens and lymph nodes from patients with Hodgkin's disease. Cancer Research, 42(5), 2063-2068.