Abstract
We have compared the levels of natural killer (NK) activity and of tumor necrosis factor-α (TNF-α) and interferon-γ, (IFN-γ) production in human immunodeficiency virus (HIV)-infected children (HIV+) with those of HIV- negative (HIV-) children born to HIV+ mothers. NK activity was significantly lower in HIV+ children than in HIV- controls (p <0.05), except for the group with the lowest CD4+ count and with opportunistic infections. Cells with NK phenotype were also fewer in the HIV+ group, although there was an increase in activated T lymphocytes DR+ CD3+ (p <0.05), related to increased CD8+ CD57+ cells. TNF-α and IFN-γ production was greater in HIV+ patients than in controls (p = 0.052; p <0.05). This difference was due to patients with lymphocytic interstitial pneumonitis (LIP), who had significantly higher levels of TNF-α and IFN-γ than the other HIV+ children (p <0.002; p <0.003) or the control group (p <0.001). Neither p24 antigenemia nor decreased numbers of CD4+ cells were associated with increased levels of these cytokines.
| Original language | English |
|---|---|
| Pages (from-to) | 204-211 |
| Number of pages | 8 |
| Journal | Pediatric AIDS and HIV Infection |
| Volume | 6 |
| Issue number | 4 |
| Publication status | Published - 1995 |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
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Natural killer activity, tumor necrosis factor-α, and interferon-γ, production in HIV-infected children at various stages of disease. / Radelli, L.; Hu, C.; Birindelli, S.; Bray, M.; Monza, M.; Plebani, A.; Scorza, R.
In: Pediatric AIDS and HIV Infection, Vol. 6, No. 4, 1995, p. 204-211.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Natural killer activity, tumor necrosis factor-α, and interferon-γ, production in HIV-infected children at various stages of disease
AU - Radelli, L.
AU - Hu, C.
AU - Birindelli, S.
AU - Bray, M.
AU - Monza, M.
AU - Plebani, A.
AU - Scorza, R.
PY - 1995
Y1 - 1995
N2 - We have compared the levels of natural killer (NK) activity and of tumor necrosis factor-α (TNF-α) and interferon-γ, (IFN-γ) production in human immunodeficiency virus (HIV)-infected children (HIV+) with those of HIV- negative (HIV-) children born to HIV+ mothers. NK activity was significantly lower in HIV+ children than in HIV- controls (p <0.05), except for the group with the lowest CD4+ count and with opportunistic infections. Cells with NK phenotype were also fewer in the HIV+ group, although there was an increase in activated T lymphocytes DR+ CD3+ (p <0.05), related to increased CD8+ CD57+ cells. TNF-α and IFN-γ production was greater in HIV+ patients than in controls (p = 0.052; p <0.05). This difference was due to patients with lymphocytic interstitial pneumonitis (LIP), who had significantly higher levels of TNF-α and IFN-γ than the other HIV+ children (p <0.002; p <0.003) or the control group (p <0.001). Neither p24 antigenemia nor decreased numbers of CD4+ cells were associated with increased levels of these cytokines.
AB - We have compared the levels of natural killer (NK) activity and of tumor necrosis factor-α (TNF-α) and interferon-γ, (IFN-γ) production in human immunodeficiency virus (HIV)-infected children (HIV+) with those of HIV- negative (HIV-) children born to HIV+ mothers. NK activity was significantly lower in HIV+ children than in HIV- controls (p <0.05), except for the group with the lowest CD4+ count and with opportunistic infections. Cells with NK phenotype were also fewer in the HIV+ group, although there was an increase in activated T lymphocytes DR+ CD3+ (p <0.05), related to increased CD8+ CD57+ cells. TNF-α and IFN-γ production was greater in HIV+ patients than in controls (p = 0.052; p <0.05). This difference was due to patients with lymphocytic interstitial pneumonitis (LIP), who had significantly higher levels of TNF-α and IFN-γ than the other HIV+ children (p <0.002; p <0.003) or the control group (p <0.001). Neither p24 antigenemia nor decreased numbers of CD4+ cells were associated with increased levels of these cytokines.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029144969&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0029144969
VL - 6
SP - 204
EP - 211
JO - Pediatric AIDS and HIV Infection
JF - Pediatric AIDS and HIV Infection
SN - 1045-5418
IS - 4
ER -