Natural killer activity, tumor necrosis factor-α, and interferon-γ, production in HIV-infected children at various stages of disease

L. Radelli, C. Hu, S. Birindelli, M. Bray, M. Monza, A. Plebani, R. Scorza

Research output: Contribution to journalArticle

Abstract

We have compared the levels of natural killer (NK) activity and of tumor necrosis factor-α (TNF-α) and interferon-γ, (IFN-γ) production in human immunodeficiency virus (HIV)-infected children (HIV+) with those of HIV- negative (HIV-) children born to HIV+ mothers. NK activity was significantly lower in HIV+ children than in HIV- controls (p <0.05), except for the group with the lowest CD4+ count and with opportunistic infections. Cells with NK phenotype were also fewer in the HIV+ group, although there was an increase in activated T lymphocytes DR+ CD3+ (p <0.05), related to increased CD8+ CD57+ cells. TNF-α and IFN-γ production was greater in HIV+ patients than in controls (p = 0.052; p <0.05). This difference was due to patients with lymphocytic interstitial pneumonitis (LIP), who had significantly higher levels of TNF-α and IFN-γ than the other HIV+ children (p <0.002; p <0.003) or the control group (p <0.001). Neither p24 antigenemia nor decreased numbers of CD4+ cells were associated with increased levels of these cytokines.

Original languageEnglish
Pages (from-to)204-211
Number of pages8
JournalPediatric AIDS and HIV Infection
Volume6
Issue number4
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Radelli, L., Hu, C., Birindelli, S., Bray, M., Monza, M., Plebani, A., & Scorza, R. (1995). Natural killer activity, tumor necrosis factor-α, and interferon-γ, production in HIV-infected children at various stages of disease. Pediatric AIDS and HIV Infection, 6(4), 204-211.