Natural killer alloeffector responses in haploidentical hemopoietic stem cell transplantation to treat high-risk leukemias

Research output: Contribution to journalArticlepeer-review

Abstract

Natural killer (NK) cells, a major cell type of the innate immunity, express surface receptors that regulate potent effector functions such as cytolytic activity and release of cytokines playing a central role in inflammatory response and immunoregulation. In this contribution, we briefly outline the major steps from the discovery of human leukocyte antigen (HLA)-class I-specific inhibitory receptors in humans to recent successful clinical applications in the cure of high-risk leukemias both in adults and in pediatric patients. A central role is played by 'alloreactive' NK cells originated from donor's CD 34+ cells in eradicating leukemic cells in the setting of T-cell-depleted haploidentical hemopoietic stem cell transplantation. Because alloreactive NK cells play a central role also in preventing graft rejection and graft- vs-host disease, they may represent an ideal tool to treat patients affected by acute high-risk leukemias.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalTissue Antigens
Volume75
Issue number2
DOIs
Publication statusPublished - Feb 2010

Keywords

  • Activating receptors
  • Acute lymphoblastic leukemias
  • Acute myeloid leukemias
  • Hemopoietic stem cell transplantation
  • Killer immunoglobulin-like receptors
  • Killer immunoglobulin-like repertoire
  • Natural killer cells

ASJC Scopus subject areas

  • Genetics
  • Immunology
  • Immunology and Allergy

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