Linfomi-t cutanei citotossici e natural killer

Translated title of the contribution: Natural killer and t-cell cytotoxic cutaneous lymphomas

Research output: Contribution to journalArticlepeer-review


In the group of primary cutaneous T-cell lymphomas, T-cytotoxic and natural killer cell lymphomas have been recently recognized as distinct and rare clinicopathologic entities. Typically, cytotoxic granules associated proteins TIA-1, granulolysine and perform, and cytotoxic-natural killer (NK) cell markers CD8+, CD56+, CD94+, CD161+, NKp46+ are expressed by tumoral cells. Five T-cytotoxic and NK cutaneous lymphomas subtypes are actually recognized: subcutaneous panniculitis-like T-cell lymphoma, extranodal nasal and nasal-type NK-T cell lymphoma, blastic NK cell lymphoma, aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma, cutaneous gamma-delta peripheral T-cell lymphoma. In this review, the most important clinical, histological, immunohistochemical and molecular data are analyzed together with differential diagnostic aspects between these entities. T-cytotoxic and NK cutaneous lymphomas pursue a very aggressive course, with poor outcome and high mortality rate, with few exceptions.

Translated title of the contributionNatural killer and t-cell cytotoxic cutaneous lymphomas
Original languageItalian
Pages (from-to)249-261
Number of pages13
JournalGiornale Italiano di Dermatologia e Venereologia
Issue number3
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Dermatology


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