Natural killer cell activity in endometriosis: Correlation between serum estradiol levels and cytotoxicity

G. G. Garzetti, A. Ciavattini, M. Provinciali, N. Fabris, M. Cignitti, C. Romanini

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate the correlation between natural killer cell activity and serum estradiol (E2) levels in patients with different stages of endometriosis. Methods: Natural killer cell activity of peripheral blood lymphocytes and serum E2 levels were evaluated in 73 women who underwent laparoscopy for pelvic pain, infertility, and benign adnexal masses. Results: The 33 patients (45%) with endometriosis showed a significant decrease in natural killer cell activity in relationship to an increase in disease stage (correlation coefficient r = -0.83, P <.001). A significant inverse relationship was observed between cytotoxicity and serum E2 levels (correlation coefficient r = -0.89, P <.001). Conclusion: The relationship between natural killer cell activity and serum E2 levels suggests that an immunoendocrine interaction plays an important role in the progression of endometriosis.

Original languageEnglish
Pages (from-to)665-668
Number of pages4
JournalObstetrics and Gynecology
Volume81
Issue number5 I
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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