Natural killer cell activity in endometriosis: Correlation between serum estradiol levels and cytotoxicity

G. G. Garzetti; A. Ciavattini; M. Provinciali; N. Fabris; M. Cignitti; C. Romanini

Natural killer cell activity in endometriosis: Correlation between serum estradiol levels and cytotoxicity

G. G. Garzetti, A. Ciavattini, M. Provinciali, N. Fabris, M. Cignitti, C. Romanini

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To evaluate the correlation between natural killer cell activity and serum estradiol (E2) levels in patients with different stages of endometriosis. Methods: Natural killer cell activity of peripheral blood lymphocytes and serum E2 levels were evaluated in 73 women who underwent laparoscopy for pelvic pain, infertility, and benign adnexal masses. Results: The 33 patients (45%) with endometriosis showed a significant decrease in natural killer cell activity in relationship to an increase in disease stage (correlation coefficient r = -0.83, P <.001). A significant inverse relationship was observed between cytotoxicity and serum E2 levels (correlation coefficient r = -0.89, P <.001). Conclusion: The relationship between natural killer cell activity and serum E2 levels suggests that an immunoendocrine interaction plays an important role in the progression of endometriosis.

Original language	English
Pages (from-to)	665-668
Number of pages	4
Journal	Obstetrics and Gynecology
Volume	81
Issue number	5 I
Publication status	Published - 1993

ASJC Scopus subject areas

Obstetrics and Gynaecology

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title = "Natural killer cell activity in endometriosis: Correlation between serum estradiol levels and cytotoxicity",

abstract = "Objective: To evaluate the correlation between natural killer cell activity and serum estradiol (E2) levels in patients with different stages of endometriosis. Methods: Natural killer cell activity of peripheral blood lymphocytes and serum E2 levels were evaluated in 73 women who underwent laparoscopy for pelvic pain, infertility, and benign adnexal masses. Results: The 33 patients (45%) with endometriosis showed a significant decrease in natural killer cell activity in relationship to an increase in disease stage (correlation coefficient r = -0.83, P <.001). A significant inverse relationship was observed between cytotoxicity and serum E2 levels (correlation coefficient r = -0.89, P <.001). Conclusion: The relationship between natural killer cell activity and serum E2 levels suggests that an immunoendocrine interaction plays an important role in the progression of endometriosis.",

author = "Garzetti, {G. G.} and A. Ciavattini and M. Provinciali and N. Fabris and M. Cignitti and C. Romanini",

year = "1993",

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TY - JOUR

T1 - Natural killer cell activity in endometriosis

T2 - Correlation between serum estradiol levels and cytotoxicity

AU - Garzetti, G. G.

AU - Ciavattini, A.

AU - Provinciali, M.

AU - Fabris, N.

AU - Cignitti, M.

AU - Romanini, C.

PY - 1993

Y1 - 1993

N2 - Objective: To evaluate the correlation between natural killer cell activity and serum estradiol (E2) levels in patients with different stages of endometriosis. Methods: Natural killer cell activity of peripheral blood lymphocytes and serum E2 levels were evaluated in 73 women who underwent laparoscopy for pelvic pain, infertility, and benign adnexal masses. Results: The 33 patients (45%) with endometriosis showed a significant decrease in natural killer cell activity in relationship to an increase in disease stage (correlation coefficient r = -0.83, P <.001). A significant inverse relationship was observed between cytotoxicity and serum E2 levels (correlation coefficient r = -0.89, P <.001). Conclusion: The relationship between natural killer cell activity and serum E2 levels suggests that an immunoendocrine interaction plays an important role in the progression of endometriosis.

AB - Objective: To evaluate the correlation between natural killer cell activity and serum estradiol (E2) levels in patients with different stages of endometriosis. Methods: Natural killer cell activity of peripheral blood lymphocytes and serum E2 levels were evaluated in 73 women who underwent laparoscopy for pelvic pain, infertility, and benign adnexal masses. Results: The 33 patients (45%) with endometriosis showed a significant decrease in natural killer cell activity in relationship to an increase in disease stage (correlation coefficient r = -0.83, P <.001). A significant inverse relationship was observed between cytotoxicity and serum E2 levels (correlation coefficient r = -0.89, P <.001). Conclusion: The relationship between natural killer cell activity and serum E2 levels suggests that an immunoendocrine interaction plays an important role in the progression of endometriosis.

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