Natural killer cells: A mystery no more

Research output: Contribution to journalArticlepeer-review


Recent years have witnessed remarkable progress in our understanding of the molecular mechanism regulating natural killer (NK) cell function. NK cells can sense whether cells have lost the surface expression of major histocompatibility complex (MHC)-class I molecules. The discovery of MHC-class I-specific inhibitory receptors clarified the basis of this discrimination and elucidated the nature of the 'off' signal. However, the receptors responsible for the 'on' signal in the process of natural cytotoxicity remained mysterious until recently. Here, we describe the identification and characterization of such receptors and discuss the emerging implications of these findings in different diseases.

Original languageEnglish
Pages (from-to)229-232
Number of pages4
JournalScandinavian Journal of Immunology
Issue number3
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Immunology


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