Natural killer cells carry the germ-line configuration of the T cell receptor δ chain gene and heterogeneously express six distinct δ transcripts

Alessandra Carè; Pier G. Pelicci; Ettore Meccia; Marta Fagioli; Ugo Testa; Ermanno Ciccone; Alessandro Moretta; Lorenzo Moretta; Cesare Peschle

Natural killer cells carry the germ-line configuration of the T cell receptor δ chain gene and heterogeneously express six distinct δ transcripts

Alessandra Carè, Pier G. Pelicci, Ettore Meccia, Marta Fagioli, Ugo Testa, Ermanno Ciccone, Alessandro Moretta, Lorenzo Moretta, Cesare Peschle

Research output: Contribution to journal › Article › peer-review

Abstract

Investigations on T cell receptor δ chain (TcR δ) gene expression in freshly isolated normal large granular lymphocytes, natural killer (NK) cell clones and NK bulk cultures revealed six Tδ transcripts (3.5, 3.1, 2.2, 2.0, 1.5 and 1.3 kb) which varied in number and relative abundance in the different samples. None of the six known Tδ variable regions was expressed and the Tδ locus was retained in its germ-line configuration. The origin and significance of these NK-associated Tδ transcripts are discussed.

Original language	English
Pages (from-to)	939-942
Number of pages	4
Journal	European Journal of Immunology
Volume	20
Issue number	4
Publication status	Published - Apr 1990

ASJC Scopus subject areas

Immunology

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Natural killer cells carry the germ-line configuration of the T cell receptor δ chain gene and heterogeneously express six distinct δ transcripts. / Carè, Alessandra; Pelicci, Pier G.; Meccia, Ettore; Fagioli, Marta; Testa, Ugo; Ciccone, Ermanno; Moretta, Alessandro; Moretta, Lorenzo; Peschle, Cesare.

In: European Journal of Immunology, Vol. 20, No. 4, 04.1990, p. 939-942.

Research output: Contribution to journal › Article › peer-review

Carè, Alessandra ; Pelicci, Pier G. ; Meccia, Ettore ; Fagioli, Marta ; Testa, Ugo ; Ciccone, Ermanno ; Moretta, Alessandro ; Moretta, Lorenzo ; Peschle, Cesare. / Natural killer cells carry the germ-line configuration of the T cell receptor δ chain gene and heterogeneously express six distinct δ transcripts. In: European Journal of Immunology. 1990 ; Vol. 20, No. 4. pp. 939-942.

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AU - Testa, Ugo

AU - Ciccone, Ermanno

AU - Moretta, Alessandro

AU - Moretta, Lorenzo

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