Natural killer cells carry the germ-line configuration of the T cell receptor δ chain gene and heterogeneously express six distinct δ transcripts

Alessandra Carè, Pier G. Pelicci, Ettore Meccia, Marta Fagioli, Ugo Testa, Ermanno Ciccone, Alessandro Moretta, Lorenzo Moretta, Cesare Peschle

Research output: Contribution to journalArticlepeer-review

Abstract

Investigations on T cell receptor δ chain (TcR δ) gene expression in freshly isolated normal large granular lymphocytes, natural killer (NK) cell clones and NK bulk cultures revealed six Tδ transcripts (3.5, 3.1, 2.2, 2.0, 1.5 and 1.3 kb) which varied in number and relative abundance in the different samples. None of the six known Tδ variable regions was expressed and the Tδ locus was retained in its germ-line configuration. The origin and significance of these NK-associated Tδ transcripts are discussed.

Original languageEnglish
Pages (from-to)939-942
Number of pages4
JournalEuropean Journal of Immunology
Volume20
Issue number4
Publication statusPublished - Apr 1990

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Natural killer cells carry the germ-line configuration of the T cell receptor δ chain gene and heterogeneously express six distinct δ transcripts'. Together they form a unique fingerprint.

Cite this