Natural killer cells: From surface receptors to the cure of high-risk leukemia (Ceppellini Lecture)

Research output: Contribution to journalReview article

Abstract

Natural killer (NK) cells are innate immune effector cells involved in the first line of defense against viral infections and malignancies. In the last three decades, the identification of HLA class I-specific inhibitory killer immunoglobulin-like receptors (KIR) and of the main activating receptors has strongly improved our understanding of the mechanisms regulating NK cell functions. The increased knowledge on how NK cells discriminate healthy cells from damaged cells has made it possible to transfer basic research notions to clinical applications. Of particular relevance is the strong NK-mediated anti-leukemia effect in haploidentical hematopoietic stem cell transplantation to cure high-risk leukemia.

Original languageEnglish
Pages (from-to)185-194
Number of pages10
JournalHLA
Volume93
Issue number4
DOIs
Publication statusPublished - Apr 2019

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Cell Surface Receptors
Natural Killer Cells
Leukemia
KIR Receptors
Hematopoietic Stem Cell Transplantation
Virus Diseases
Research
Neoplasms

Cite this

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title = "Natural killer cells: From surface receptors to the cure of high-risk leukemia (Ceppellini Lecture)",
abstract = "Natural killer (NK) cells are innate immune effector cells involved in the first line of defense against viral infections and malignancies. In the last three decades, the identification of HLA class I-specific inhibitory killer immunoglobulin-like receptors (KIR) and of the main activating receptors has strongly improved our understanding of the mechanisms regulating NK cell functions. The increased knowledge on how NK cells discriminate healthy cells from damaged cells has made it possible to transfer basic research notions to clinical applications. Of particular relevance is the strong NK-mediated anti-leukemia effect in haploidentical hematopoietic stem cell transplantation to cure high-risk leukemia.",
author = "Michela Falco and Daniela Pende and Enrico Munari and Paola Vacca and Mingari, {Maria C} and Lorenzo Moretta",
note = "{\circledC} 2019 The Authors. HLA: Immune Response Genetics Published by John Wiley & Sons Ltd.",
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T1 - Natural killer cells

T2 - From surface receptors to the cure of high-risk leukemia (Ceppellini Lecture)

AU - Falco, Michela

AU - Pende, Daniela

AU - Munari, Enrico

AU - Vacca, Paola

AU - Mingari, Maria C

AU - Moretta, Lorenzo

N1 - © 2019 The Authors. HLA: Immune Response Genetics Published by John Wiley & Sons Ltd.

PY - 2019/4

Y1 - 2019/4

N2 - Natural killer (NK) cells are innate immune effector cells involved in the first line of defense against viral infections and malignancies. In the last three decades, the identification of HLA class I-specific inhibitory killer immunoglobulin-like receptors (KIR) and of the main activating receptors has strongly improved our understanding of the mechanisms regulating NK cell functions. The increased knowledge on how NK cells discriminate healthy cells from damaged cells has made it possible to transfer basic research notions to clinical applications. Of particular relevance is the strong NK-mediated anti-leukemia effect in haploidentical hematopoietic stem cell transplantation to cure high-risk leukemia.

AB - Natural killer (NK) cells are innate immune effector cells involved in the first line of defense against viral infections and malignancies. In the last three decades, the identification of HLA class I-specific inhibitory killer immunoglobulin-like receptors (KIR) and of the main activating receptors has strongly improved our understanding of the mechanisms regulating NK cell functions. The increased knowledge on how NK cells discriminate healthy cells from damaged cells has made it possible to transfer basic research notions to clinical applications. Of particular relevance is the strong NK-mediated anti-leukemia effect in haploidentical hematopoietic stem cell transplantation to cure high-risk leukemia.

U2 - 10.1111/tan.13509

DO - 10.1111/tan.13509

M3 - Review article

C2 - 30828978

VL - 93

SP - 185

EP - 194

JO - HLA

JF - HLA

SN - 2059-2302

IS - 4

ER -