Fetal tissues in contact with mother's blood lack classical HLA-class I molecules, thus escaping T cell-mediated recognition and rejection. However, how does the fetus escape killing by NK cells which sense the lack of HLA expression? Here, Maria Cristina Mingari and colleagues address this question and report recent data indicating that, during pregnancy, maternal NK cells display a general upregulation of inhibitory receptors specific for HLA-G. More importantly, all decidua-associated NK cells express one or more of these receptors, thus preventing their attack of fetal tissues.
|Number of pages||5|
|Publication status||Published - 1999|
ASJC Scopus subject areas
- Cell Biology