Natural killer (NK) cells from killers to regulators: Distinct features between peripheral blood and decidual NK cells

Angela Santoni, Alessandra Zingoni, Cristina Cerboni, Angela Gismondi

Research output: Contribution to journalArticle

Abstract

Natural killer (NK) cells are a key component of innate immunity, particularly crucial during the early phase of immune responses against certain viruses, parasites, and microbial pathogens. The role of NK cell during pregnancy has been vividly discussed over the past years and it is now becoming increasingly clear that NK cells control pregnancy maintenance at several levels. In normal pregnancy, it appears that they provide benefit by properly secreting cytokines, chemokines and angiogenic factors rather than functioning as cytotoxic effector cells. However, as they are endowed with all the cytolytic weapons, they promptly become capable of attacking fetal and maternal tissues during infection and inflammation.

Original languageEnglish
Pages (from-to)280-288
Number of pages9
JournalAmerican Journal of Reproductive Immunology
Volume58
Issue number3
DOIs
Publication statusPublished - Sep 2007

Keywords

  • Angiogenesis
  • Chemokines
  • Cytokines
  • Migration
  • Natural killer cells
  • Uterine NK cells

ASJC Scopus subject areas

  • Immunology
  • Obstetrics and Gynaecology

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