Abstract
Obesity correlates with insulin resistance, dyslipidemia, oxidative stress, cardiovascular diseases. Meal replacement (MR) products offer a possible strategy for weight management and subsequent reduction in obesity-related risk factors. Aims/Methods: Twenty-seven healthy overweight subjects (6M/21F, age range 21-70, BMI range 25.0-43.8 kg/m2) were enrolled to test the efficacy of a MR supplement (Go- JuvoR). Main aims: A) short-term: To compare glycaemic status and triglycerides levels at baseline (T0), after MR supplementation and after a standard Mediterranean meal taken 4 hours after MR; long-term: To evaluate, in 20 out of the 27 subjects, over three months (T1), the effects of the MR, b) taken together with a standard prescribed diet, and to compare it with the effects on the parameters of 20 controls only on the standard diet. Anthropometric parameters, lipid and glycaemia profile, oxidative status (oxidized LDL concentrations) and homocysteine metabolism were measured at T0 and T1. Results: Short-term aim: Overweight/obese subjects' post-prandial MR insulin and triglycerides values were significantly lower than values after the standard meal (mean delta values p=0.0001 and p=0.006, respectively); long-term aim: At T1, subjects showed a significant improvement in anthropometric indices (p<0.05), a considerable decrease in ox-LDL levels and a significant improvement in Hcy metabolism (p<0.001). Conclusions: GoJuvoR modulated metabolic indices associated with the development of type 2 diabetes, possibly due to its fibre content. Subjects at T1 showed a significant decrease in homocysteinemia with an increase in folate levels and an anti-oxidative action on lipid peroxidation, most likely contributing to a reduction in cardiovascular risk.
| Original language | English |
|---|---|
| Pages (from-to) | 127-137 |
| Number of pages | 11 |
| Journal | Progress in Nutrition |
| Volume | 19 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2017 |
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Keywords
- fibre
- glycaemic index
- insulin resistance
- meal replacement
- obesity
- oxidative status
ASJC Scopus subject areas
- Food Science
- Nutrition and Dietetics
Cite this
Natural vegan meal replacement : Metabolic and oxidative modulation on overweight subjects. / Vigna, Luisella; Galimberti, Daniela; De Giuseppe, Rachele; Cossovich, Anna; Sommaruga, Daniela; De Liso, Federica; Gori, Francesca; Ingenito, Maria Rosaria; Napolitano, Filomena; Tomaino, Laura; Novembrino, Cristina; Fenoglio, Chiara; Bamonti, Fabrizia.
In: Progress in Nutrition, Vol. 19, No. 2, 2017, p. 127-137.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Natural vegan meal replacement
T2 - Metabolic and oxidative modulation on overweight subjects
AU - Vigna, Luisella
AU - Galimberti, Daniela
AU - De Giuseppe, Rachele
AU - Cossovich, Anna
AU - Sommaruga, Daniela
AU - De Liso, Federica
AU - Gori, Francesca
AU - Ingenito, Maria Rosaria
AU - Napolitano, Filomena
AU - Tomaino, Laura
AU - Novembrino, Cristina
AU - Fenoglio, Chiara
AU - Bamonti, Fabrizia
PY - 2017
Y1 - 2017
N2 - Obesity correlates with insulin resistance, dyslipidemia, oxidative stress, cardiovascular diseases. Meal replacement (MR) products offer a possible strategy for weight management and subsequent reduction in obesity-related risk factors. Aims/Methods: Twenty-seven healthy overweight subjects (6M/21F, age range 21-70, BMI range 25.0-43.8 kg/m2) were enrolled to test the efficacy of a MR supplement (Go- JuvoR). Main aims: A) short-term: To compare glycaemic status and triglycerides levels at baseline (T0), after MR supplementation and after a standard Mediterranean meal taken 4 hours after MR; long-term: To evaluate, in 20 out of the 27 subjects, over three months (T1), the effects of the MR, b) taken together with a standard prescribed diet, and to compare it with the effects on the parameters of 20 controls only on the standard diet. Anthropometric parameters, lipid and glycaemia profile, oxidative status (oxidized LDL concentrations) and homocysteine metabolism were measured at T0 and T1. Results: Short-term aim: Overweight/obese subjects' post-prandial MR insulin and triglycerides values were significantly lower than values after the standard meal (mean delta values p=0.0001 and p=0.006, respectively); long-term aim: At T1, subjects showed a significant improvement in anthropometric indices (p<0.05), a considerable decrease in ox-LDL levels and a significant improvement in Hcy metabolism (p<0.001). Conclusions: GoJuvoR modulated metabolic indices associated with the development of type 2 diabetes, possibly due to its fibre content. Subjects at T1 showed a significant decrease in homocysteinemia with an increase in folate levels and an anti-oxidative action on lipid peroxidation, most likely contributing to a reduction in cardiovascular risk.
AB - Obesity correlates with insulin resistance, dyslipidemia, oxidative stress, cardiovascular diseases. Meal replacement (MR) products offer a possible strategy for weight management and subsequent reduction in obesity-related risk factors. Aims/Methods: Twenty-seven healthy overweight subjects (6M/21F, age range 21-70, BMI range 25.0-43.8 kg/m2) were enrolled to test the efficacy of a MR supplement (Go- JuvoR). Main aims: A) short-term: To compare glycaemic status and triglycerides levels at baseline (T0), after MR supplementation and after a standard Mediterranean meal taken 4 hours after MR; long-term: To evaluate, in 20 out of the 27 subjects, over three months (T1), the effects of the MR, b) taken together with a standard prescribed diet, and to compare it with the effects on the parameters of 20 controls only on the standard diet. Anthropometric parameters, lipid and glycaemia profile, oxidative status (oxidized LDL concentrations) and homocysteine metabolism were measured at T0 and T1. Results: Short-term aim: Overweight/obese subjects' post-prandial MR insulin and triglycerides values were significantly lower than values after the standard meal (mean delta values p=0.0001 and p=0.006, respectively); long-term aim: At T1, subjects showed a significant improvement in anthropometric indices (p<0.05), a considerable decrease in ox-LDL levels and a significant improvement in Hcy metabolism (p<0.001). Conclusions: GoJuvoR modulated metabolic indices associated with the development of type 2 diabetes, possibly due to its fibre content. Subjects at T1 showed a significant decrease in homocysteinemia with an increase in folate levels and an anti-oxidative action on lipid peroxidation, most likely contributing to a reduction in cardiovascular risk.
KW - fibre
KW - glycaemic index
KW - insulin resistance
KW - meal replacement
KW - obesity
KW - oxidative status
UR - http://www.scopus.com/inward/record.url?scp=85025818509&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85025818509&partnerID=8YFLogxK
U2 - 10.23751/pn.v19i2.4774
DO - 10.23751/pn.v19i2.4774
M3 - Article
VL - 19
SP - 127
EP - 137
JO - Progress in Nutrition
JF - Progress in Nutrition
SN - 1129-8723
IS - 2
ER -