Natural vitamin C intake and the risk of head and neck cancer: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

Valeria Edefonti, Mia Hashibe, Maria Parpinel, Federica Turati, Diego Serraino, Keitaro Matsuo, Andrew F. Olshan, Jose P. Zevallos, Deborah M. Winn, Kirsten Moysich, Zuo Feng Zhang, Hal Morgenstern, Fabio Levi, Karl Kelsey, Michael McClean, Cristina Bosetti, Carlotta Galeone, Stimson Schantz, Guo Pei Yu, Paolo BoffettaYuan Chin Amy Lee, Shu Chun Chuang, Carlo La Vecchia, Adriano Decarli

Research output: Contribution to journalArticle

Abstract

Evidence of associations between single nutrients and head and neck cancer (HNC) is still more limited and less consistent than that for fruit and vegetables. However, clarification of the protective mechanisms of fruit and vegetables is important to our understanding of HNC etiology. We investigated the association between vitamin C intake from natural sources and cancer of the oral cavity/pharynx and larynx using individual-level pooled data from ten case-control studies (5,959 cases and 12,248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. After harmonization of study-specific exposure information via the residual method, adjusted odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using unconditional multiple logistic regression models on quintile categories of 'non-alcohol energy-adjusted' vitamin C intake. In the presence of heterogeneity of the estimated ORs among studies, we derived those estimates from generalized linear mixed models. Higher intakes of vitamin C were inversely related to oral and pharyngeal (OR = 0.54, 95% CI: 0.45-0.65, for the fifth quintile category versus the first one, p for trend

Original languageEnglish
Pages (from-to)448-462
Number of pages15
JournalInternational Journal of Cancer
Volume137
Issue number2
DOIs
Publication statusPublished - Jul 15 2015

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Keywords

  • head and neck cancer
  • INHANCE
  • laryngeal cancer
  • oral and pharyngeal cancer
  • vitamin C

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Edefonti, V., Hashibe, M., Parpinel, M., Turati, F., Serraino, D., Matsuo, K., Olshan, A. F., Zevallos, J. P., Winn, D. M., Moysich, K., Zhang, Z. F., Morgenstern, H., Levi, F., Kelsey, K., McClean, M., Bosetti, C., Galeone, C., Schantz, S., Yu, G. P., ... Decarli, A. (2015). Natural vitamin C intake and the risk of head and neck cancer: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. International Journal of Cancer, 137(2), 448-462. https://doi.org/10.1002/ijc.29388