Natural zeolites chabazite/phillipsite/analcime increase blood levels of antioxidant enzymes

Giada Dogliotti, Alexis E. Malavazos, Sonia Giacometti, Umberto Solimene, Mauro Fanelli, Massimiliano M. Corsi, Elena Dozio

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Imbalance,betweenoreactive oxygen species generation andeantioxidant capacity induces a condition known as oxidative stress which is implicated in numerous pathological processes. In this study we evaluated whether natural zeolites chabazite/phillipsite/analcime may affect the levels of different antioxidant enzymes (gluthatione peroxidase, superoxide dismutase, gluthatione reductase), total antioxidant status and oxidative stress in 25 clinically healthy men, both non-smokers and smokers. Measurements were performed on whole blood or on plasma samples before (T0) and after 4-weeks zeolites intake (T1). At T1, gluthatione peroxidase, superoxide dismutase and gluthatione reductase increased compared to T0 levels, both considering all subjects as joint and after subdivision in non-smokers and smokers. Differently, a reduction in total antioxidant status was observed at T1. Anyway, total antioxidant status resulted higher than the reference values in both groups at each time point. A decrease in lipid peroxidation, a major indicator of oxidative stress assessed by monitoring thiobarbituric acid reactive substances, was also observed in all subjects at T1. Our results suggested that chabazite/phillipsite/analcime may help to counteract oxidative stress in apparently healthy subjects exposed to different oxidative stress risk factors, such as smoking, thus representing a particular kind of food with potential antioxidant properties.

Original languageEnglish
Pages (from-to)195-198
Number of pages4
JournalJournal of Clinical Biochemistry and Nutrition
Volume50
Issue number3
DOIs
Publication statusPublished - May 2012

Fingerprint

Zeolites
Oxidative stress
Oxidative Stress
Blood
Antioxidants
Enzymes
Peroxidase
Superoxide Dismutase
Oxidoreductases
Thiobarbituric Acid Reactive Substances
Pathologic Processes
Lipid Peroxidation
Healthy Volunteers
Reference Values
Joints
Smoking
phillipsite
chabazite
Oxygen
Lipids

Keywords

  • Gluthatione peroxidase
  • Gluthatione reductase
  • Superoxide dismutase
  • Total antioxidant status
  • Zeolites

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Natural zeolites chabazite/phillipsite/analcime increase blood levels of antioxidant enzymes. / Dogliotti, Giada; Malavazos, Alexis E.; Giacometti, Sonia; Solimene, Umberto; Fanelli, Mauro; Corsi, Massimiliano M.; Dozio, Elena.

In: Journal of Clinical Biochemistry and Nutrition, Vol. 50, No. 3, 05.2012, p. 195-198.

Research output: Contribution to journalArticle

Dogliotti, Giada ; Malavazos, Alexis E. ; Giacometti, Sonia ; Solimene, Umberto ; Fanelli, Mauro ; Corsi, Massimiliano M. ; Dozio, Elena. / Natural zeolites chabazite/phillipsite/analcime increase blood levels of antioxidant enzymes. In: Journal of Clinical Biochemistry and Nutrition. 2012 ; Vol. 50, No. 3. pp. 195-198.
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