Natural zeolites chabazite/phillipsite/analcime increase blood levels of antioxidant enzymes

Giada Dogliotti, Alexis E. Malavazos, Sonia Giacometti, Umberto Solimene, Mauro Fanelli, Massimiliano M. Corsi, Elena Dozio

Research output: Contribution to journalArticlepeer-review


Imbalance,betweenoreactive oxygen species generation andeantioxidant capacity induces a condition known as oxidative stress which is implicated in numerous pathological processes. In this study we evaluated whether natural zeolites chabazite/phillipsite/analcime may affect the levels of different antioxidant enzymes (gluthatione peroxidase, superoxide dismutase, gluthatione reductase), total antioxidant status and oxidative stress in 25 clinically healthy men, both non-smokers and smokers. Measurements were performed on whole blood or on plasma samples before (T0) and after 4-weeks zeolites intake (T1). At T1, gluthatione peroxidase, superoxide dismutase and gluthatione reductase increased compared to T0 levels, both considering all subjects as joint and after subdivision in non-smokers and smokers. Differently, a reduction in total antioxidant status was observed at T1. Anyway, total antioxidant status resulted higher than the reference values in both groups at each time point. A decrease in lipid peroxidation, a major indicator of oxidative stress assessed by monitoring thiobarbituric acid reactive substances, was also observed in all subjects at T1. Our results suggested that chabazite/phillipsite/analcime may help to counteract oxidative stress in apparently healthy subjects exposed to different oxidative stress risk factors, such as smoking, thus representing a particular kind of food with potential antioxidant properties.

Original languageEnglish
Pages (from-to)195-198
Number of pages4
JournalJournal of Clinical Biochemistry and Nutrition
Issue number3
Publication statusPublished - May 2012


  • Gluthatione peroxidase
  • Gluthatione reductase
  • Superoxide dismutase
  • Total antioxidant status
  • Zeolites

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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