Abstract
Venocclusive disease (VOD) of the liver is the major dose-limiting complication of pretransplant regimens for bone marrow transplantation. Recent reports from different groups point to the involvement of the hemostatic mechanism in the development of VOD. We measured the naturally occurring anticoagulants protein C, antithrombin III, and protein S in 45 patients undergoing bone marrow transplantation for hematologic malignancies before cytoreductive therapy and after transplant. The aim of this prospective study was both to evaluate the status of the naturally occurring anticoagulant pathway in patients who develop VOD compared with patients who do not, and to find a predictive marker of VOD. In transplant patients, protein C decreased from before cytoreductive therapy to posttransplant, whereas protein S and antithrombin III did not. In a multivariate analysis, protein C was the only variable that could independently discriminate between VOD and non-VOD patients at all times. Discriminant function analysis established that low protein C levels before cytoreductive therapy predicted the occurrence of VOD with good sensitivity and specificity.
| Original language | English |
|---|---|
| Pages (from-to) | 3458-3462 |
| Number of pages | 5 |
| Journal | Blood |
| Volume | 81 |
| Issue number | 12 |
| Publication status | Published - Jun 15 1993 |
Fingerprint
ASJC Scopus subject areas
- Hematology
Cite this
Naturally occurring anticoagulants and bone marrow transplantation : Plasma protein C predicts the development of venocclusive disease of the liver. / Faioni, Elena M.; Krachmalnicoff, Alessandro; Bearman, Scott I.; Federici, Augusto B.; Decarli, Adriano; Gianni, Alessandro M.; McDonald, George B.; Mannucci, Pier Mannuccio.
In: Blood, Vol. 81, No. 12, 15.06.1993, p. 3458-3462.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Naturally occurring anticoagulants and bone marrow transplantation
T2 - Plasma protein C predicts the development of venocclusive disease of the liver
AU - Faioni, Elena M.
AU - Krachmalnicoff, Alessandro
AU - Bearman, Scott I.
AU - Federici, Augusto B.
AU - Decarli, Adriano
AU - Gianni, Alessandro M.
AU - McDonald, George B.
AU - Mannucci, Pier Mannuccio
PY - 1993/6/15
Y1 - 1993/6/15
N2 - Venocclusive disease (VOD) of the liver is the major dose-limiting complication of pretransplant regimens for bone marrow transplantation. Recent reports from different groups point to the involvement of the hemostatic mechanism in the development of VOD. We measured the naturally occurring anticoagulants protein C, antithrombin III, and protein S in 45 patients undergoing bone marrow transplantation for hematologic malignancies before cytoreductive therapy and after transplant. The aim of this prospective study was both to evaluate the status of the naturally occurring anticoagulant pathway in patients who develop VOD compared with patients who do not, and to find a predictive marker of VOD. In transplant patients, protein C decreased from before cytoreductive therapy to posttransplant, whereas protein S and antithrombin III did not. In a multivariate analysis, protein C was the only variable that could independently discriminate between VOD and non-VOD patients at all times. Discriminant function analysis established that low protein C levels before cytoreductive therapy predicted the occurrence of VOD with good sensitivity and specificity.
AB - Venocclusive disease (VOD) of the liver is the major dose-limiting complication of pretransplant regimens for bone marrow transplantation. Recent reports from different groups point to the involvement of the hemostatic mechanism in the development of VOD. We measured the naturally occurring anticoagulants protein C, antithrombin III, and protein S in 45 patients undergoing bone marrow transplantation for hematologic malignancies before cytoreductive therapy and after transplant. The aim of this prospective study was both to evaluate the status of the naturally occurring anticoagulant pathway in patients who develop VOD compared with patients who do not, and to find a predictive marker of VOD. In transplant patients, protein C decreased from before cytoreductive therapy to posttransplant, whereas protein S and antithrombin III did not. In a multivariate analysis, protein C was the only variable that could independently discriminate between VOD and non-VOD patients at all times. Discriminant function analysis established that low protein C levels before cytoreductive therapy predicted the occurrence of VOD with good sensitivity and specificity.
UR - http://www.scopus.com/inward/record.url?scp=0027225620&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027225620&partnerID=8YFLogxK
M3 - Article
C2 - 8507881
AN - SCOPUS:0027225620
VL - 81
SP - 3458
EP - 3462
JO - Blood
JF - Blood
SN - 0006-4971
IS - 12
ER -