Near-infrared Fluorescence-guided Sentinel Node Mapping of the Ovary With Indocyanine Green in a Minimally Invasive Setting: A Feasible Study

A. Buda, P. Passoni, G. Corrado, B. Bussi, G. Cutillo, S. Magni, E. Vizza

Research output: Contribution to journalArticle

Abstract

Sentinel lymph node (SLN) mapping has increased its feasibility in both early-stage cervical and endometrial cancer. There are few SLN studies regarding the ovary because of the risk of tumor dissemination and perhaps because the ovary represents an inconvenient site for injection. In this preliminary study, we have shown the feasibility of SLN mapping of the ovary with indocyanine green during laparoscopic retroperitoneal aortic surgical staging. The 10 women who were included in this study underwent aortic with pelvic laparoscopic staging, which included SLN biopsy, extrafascial total hysterectomy, and bilateral salpingo-oophorectomy in case of an ovarian tumor. The fluorescent dye was injected on the dorsal and ventral side of the proper ovarian ligament and the suspensory ligament, close to the ovary and just underneath the peritoneum. In all cases except 1, SLNs were detected soon after the injection in the aortic compartment and in 3 cases also in the common iliac region. Only 1 intraoperative complication occurred: a superficial lesion of the vena cava that was recovered with a laparoscopic suture. Laparoscopic ovarian SLN mapping performed by means of an injection of indocyanine green fluorescent tracer in the ovarian ligaments seems feasible and promising. Further investigation are encouraged and necessary to evaluate the possible applications of this new technique for staging patients with early-stage ovarian cancer.
Original languageEnglish
Pages (from-to)165-170
Number of pages6
JournalJournal of Minimally Invasive Gynecology
Volume24
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Indocyanine Green
Ovary
Fluorescence
Ligaments
Injections
Sentinel Lymph Node Biopsy
Venae Cavae
Peritoneum
Intraoperative Complications
Ovariectomy
Endometrial Neoplasms
Hysterectomy
Fluorescent Dyes
Uterine Cervical Neoplasms
Ovarian Neoplasms
Sutures
Neoplasms
Sentinel Lymph Node
cyhalothrin

Keywords

  • Laparoscopic surgery
  • Ovarian lymphatic drainage
  • Real-time fluorescence
  • Sentinel lymph node

Cite this

@article{d486c6e6df354e3d95181a9bf38d6873,
title = "Near-infrared Fluorescence-guided Sentinel Node Mapping of the Ovary With Indocyanine Green in a Minimally Invasive Setting: A Feasible Study",
abstract = "Sentinel lymph node (SLN) mapping has increased its feasibility in both early-stage cervical and endometrial cancer. There are few SLN studies regarding the ovary because of the risk of tumor dissemination and perhaps because the ovary represents an inconvenient site for injection. In this preliminary study, we have shown the feasibility of SLN mapping of the ovary with indocyanine green during laparoscopic retroperitoneal aortic surgical staging. The 10 women who were included in this study underwent aortic with pelvic laparoscopic staging, which included SLN biopsy, extrafascial total hysterectomy, and bilateral salpingo-oophorectomy in case of an ovarian tumor. The fluorescent dye was injected on the dorsal and ventral side of the proper ovarian ligament and the suspensory ligament, close to the ovary and just underneath the peritoneum. In all cases except 1, SLNs were detected soon after the injection in the aortic compartment and in 3 cases also in the common iliac region. Only 1 intraoperative complication occurred: a superficial lesion of the vena cava that was recovered with a laparoscopic suture. Laparoscopic ovarian SLN mapping performed by means of an injection of indocyanine green fluorescent tracer in the ovarian ligaments seems feasible and promising. Further investigation are encouraged and necessary to evaluate the possible applications of this new technique for staging patients with early-stage ovarian cancer.",
keywords = "Laparoscopic surgery, Ovarian lymphatic drainage, Real-time fluorescence, Sentinel lymph node",
author = "A. Buda and P. Passoni and G. Corrado and B. Bussi and G. Cutillo and S. Magni and E. Vizza",
note = "LR: 20161230; CI: Copyright (c) 2016; JID: 101235322; OTO: NOTNLM; 2016/08/25 [received]; 2016/09/14 [revised]; 2016/09/15 [accepted]; ppublish",
year = "2017",
month = "1",
day = "1",
doi = "S1553-4650(16)31046-9 [pii]",
language = "English",
volume = "24",
pages = "165--170",
journal = "Journal of Minimally Invasive Gynecology",
issn = "1553-4650",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Near-infrared Fluorescence-guided Sentinel Node Mapping of the Ovary With Indocyanine Green in a Minimally Invasive Setting: A Feasible Study

AU - Buda, A.

AU - Passoni, P.

AU - Corrado, G.

AU - Bussi, B.

AU - Cutillo, G.

AU - Magni, S.

AU - Vizza, E.

N1 - LR: 20161230; CI: Copyright (c) 2016; JID: 101235322; OTO: NOTNLM; 2016/08/25 [received]; 2016/09/14 [revised]; 2016/09/15 [accepted]; ppublish

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Sentinel lymph node (SLN) mapping has increased its feasibility in both early-stage cervical and endometrial cancer. There are few SLN studies regarding the ovary because of the risk of tumor dissemination and perhaps because the ovary represents an inconvenient site for injection. In this preliminary study, we have shown the feasibility of SLN mapping of the ovary with indocyanine green during laparoscopic retroperitoneal aortic surgical staging. The 10 women who were included in this study underwent aortic with pelvic laparoscopic staging, which included SLN biopsy, extrafascial total hysterectomy, and bilateral salpingo-oophorectomy in case of an ovarian tumor. The fluorescent dye was injected on the dorsal and ventral side of the proper ovarian ligament and the suspensory ligament, close to the ovary and just underneath the peritoneum. In all cases except 1, SLNs were detected soon after the injection in the aortic compartment and in 3 cases also in the common iliac region. Only 1 intraoperative complication occurred: a superficial lesion of the vena cava that was recovered with a laparoscopic suture. Laparoscopic ovarian SLN mapping performed by means of an injection of indocyanine green fluorescent tracer in the ovarian ligaments seems feasible and promising. Further investigation are encouraged and necessary to evaluate the possible applications of this new technique for staging patients with early-stage ovarian cancer.

AB - Sentinel lymph node (SLN) mapping has increased its feasibility in both early-stage cervical and endometrial cancer. There are few SLN studies regarding the ovary because of the risk of tumor dissemination and perhaps because the ovary represents an inconvenient site for injection. In this preliminary study, we have shown the feasibility of SLN mapping of the ovary with indocyanine green during laparoscopic retroperitoneal aortic surgical staging. The 10 women who were included in this study underwent aortic with pelvic laparoscopic staging, which included SLN biopsy, extrafascial total hysterectomy, and bilateral salpingo-oophorectomy in case of an ovarian tumor. The fluorescent dye was injected on the dorsal and ventral side of the proper ovarian ligament and the suspensory ligament, close to the ovary and just underneath the peritoneum. In all cases except 1, SLNs were detected soon after the injection in the aortic compartment and in 3 cases also in the common iliac region. Only 1 intraoperative complication occurred: a superficial lesion of the vena cava that was recovered with a laparoscopic suture. Laparoscopic ovarian SLN mapping performed by means of an injection of indocyanine green fluorescent tracer in the ovarian ligaments seems feasible and promising. Further investigation are encouraged and necessary to evaluate the possible applications of this new technique for staging patients with early-stage ovarian cancer.

KW - Laparoscopic surgery

KW - Ovarian lymphatic drainage

KW - Real-time fluorescence

KW - Sentinel lymph node

U2 - S1553-4650(16)31046-9 [pii]

DO - S1553-4650(16)31046-9 [pii]

M3 - Article

VL - 24

SP - 165

EP - 170

JO - Journal of Minimally Invasive Gynecology

JF - Journal of Minimally Invasive Gynecology

SN - 1553-4650

IS - 1

ER -