Near-infrared fundus autofluorescence in early age-related macular degeneration

Maurizio Battaglia Parodi, Pierluigi Iacono, Alexandros Papayannis, Giorgio Alto, Alessio Buzzotta, Alessandro Arrigo, Maria Vittoria Cicinelli, Francesco Bandello

Research output: Contribution to journalArticlepeer-review


Purpose: To describe the patterns on near-infrared fundus autofluorescence in eyes affected by early age-related macular degeneration. Design: Cross-sectional observational case series. Participants: A total of 84 eyes of 84 patients suffering from early age-related macular degeneration (>63 μm but <125 μm drusen and no-to-mild retinal pigment epithelium abnormalities) were enrolled. Methods: Patients underwent best-corrected visual acuity, biomicroscopy, infrared reflectance, short-wavelength fundus autofluorescence, and near-infrared fundus autofluorescence. Eyes were classified according to different patterns of near-infrared fundus autofluorescence. Main outcome was definition of relative prevalence and features of each near-infrared fundus autofluorescence pattern; secondary outcomes were correlation between near-infrared fundus autofluorescence and short-wavelength fundus autofluorescence and between near-infrared fundus autofluorescence patterns and best-corrected visual acuity. Results: Four different patterns of near-infrared fundus autofluorescence identified: normal foveal signal (Pattern A, 7%); normal foveal signal with hyperautofluorescent/hypoautofluorescent spots not involving the fovea (Pattern B, 65.5%); hyperautofluorescent/hypoautofluorescent spots involving the fovea (Pattern C, 15.5%); patchy pattern (Pattern D, 12%). best-corrected visual acuity was lower in eyes with foveal signal alteration (Patterns C and D). Conclusion: Near-infrared fundus autofluorescence pattern in early age-related macular degeneration might be suggestive of visual function deterioration when the fovea is involved. Longitudinal studies are warranted to confirm our preliminary results.

Original languageEnglish
JournalEuropean Journal of Ophthalmology
Publication statusE-pub ahead of print - Oct 29 2019


  • age-related macular degeneration
  • drusen
  • Near-infrared autofluorescence

ASJC Scopus subject areas

  • Ophthalmology


Dive into the research topics of 'Near-infrared fundus autofluorescence in early age-related macular degeneration'. Together they form a unique fingerprint.

Cite this