Stato di male elettrico in sonno (parziale e generalizzato): Un comune meccanismo fisiopatologico di attivazione dell'attivita epilettica intercritica in differenti sindromi cliniche

Translated title of the contribution: Nearly continuous interictal epileptic discharges during sleep: A pathophysiological mechanism common to different clinical syndromes

M. G. Baglietto, F. Ferrillo, M. Beelke, R. Gaggero, E. De Negri, L. Nobili

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. The activation of interictal discharges (lEDs) by NREM sleep is a well known phenomenon in different epileptic conditions of childhood. This activation can be bilateral (but asymmetrical), diffuse or lateralized. The pathophysiological mechanism of this activation is still unknown. Experimental data revealed that the normal sleep oscillations might develop into paroxysmal synchronization. Spectral analysis is a method that quantitatively descrives the dynamics of delta (SWA, 0.5-4.5 Hz) and sigma activity (SA, 12-16 Hz) during sleep. Materials and Methods. In order to define the relationship between synchronizing mechanisms (spindles and delta activities) and lEDs activation during sleep we have performed overnight continuous EEG polisomnography study in 23 epileptic children (8 Benign Epilepsy with Rolandic Spikes, 5 Benign Epilepsy with Occipital Spikes, 3 Landau-Kleffner Syndrome and 7 Symptomatic Epilepsy) caractherized by a strong activation of IEDs during sleep. Relationship between SA and SWA and time series of IEDs were tested by means of correlation techniques after data normalization. Results. The activation of lEDs ranged from 25% to 90% of the whole NREM sleep. A higher correlation (p

Translated title of the contributionNearly continuous interictal epileptic discharges during sleep: A pathophysiological mechanism common to different clinical syndromes
Original languageItalian
Pages (from-to)235-236
Number of pages2
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number106-107
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Clinical Neurology

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