Nebulin and titin expression in Duchenne muscular dystrophy appears normal

Dieter Fürst, Rüdiger Nave, Mary Osborn, Klaus Weber, Attila Bardosi, Nicoletta Archidiacono, Mariangela Ferro, Valentino Romano, Giovanni Romeo

Research output: Contribution to journalArticlepeer-review

Abstract

Monoclonal antibodies which recognize different epitopes on either titin or nebulin show normal staining patterns on frozen sections of three muscle biopsies of Duchenne muscular dystrophy (DMD). Gel electrophoresis and immunoblotting performed on two of these muscle biopsies show the normal pattern of titin and nebulin polypeptides. Since the donor of one of these biopsies has a large deletion of the 5′-region of the DMD gene, our results argue against the recent proposal that nebulin is the gene mutated in DMD.

Original languageEnglish
Pages (from-to)49-53
Number of pages5
JournalFEBS Letters
Volume224
Issue number1
DOIs
Publication statusPublished - Nov 16 1987

Keywords

  • Duchenne muscular dystrophy
  • Gene deletion
  • Nebulin
  • Sarcomere structure
  • Titin

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology
  • Cell Biology
  • Genetics
  • Structural Biology

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