Neck Vessel Cross-Sectional Area Measured with MRI: Scan-Rescan Reproducibility for Longitudinal Evaluations

Laura Pelizzari, Maria Marcella Laganà, Dejan Jakimovski, Niels Bergsland, Jesper Hagemeier, Giuseppe Baselli, Robert Zivadinov

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: The cross-sectional area (CSA) of common carotid arteries-internal carotid arteries (CCA-ICAs), vertebral arteries (VAs), and internal jugular veins (IJVs) is influenced by aging. However, the neck vessel CSA can be affected by other factors as well, including subject positioning, hydration, and respiration, especially in longitudinal studies. This study aimed to assess scan-rescan reproducibility of CCA-ICAs, VAs, and IJVs CSA measurements in order to evaluate their feasibility for longitudinal CSA assessments, and to apply the segmentation method on a longitudinal pilot dataset. METHODS: Two set of 2-dimensional neck magnetic resonance angiography (MRA) images were acquired on a 3-T scanner from two separate datasets: 9 healthy individuals (HIs) were scanned 5 days apart (scan-rescan dataset) and 12 HIs were acquired 5 years apart (baseline-follow-up dataset). CCA-ICAs, VAs, and IJVs were segmented along the whole vessel length between C3 and C7 intervertebral spaces. Repeated measure analysis of covariance, adjusted for cervical level and sample, and Wilcoxon signed-rank sum test were used to assess the scan-rescan and baseline-follow-up CSA differences. Intraclass correlation coefficient (ICC) was also computed to evaluate scan-rescan reliability. RESULTS: No significant CSA differences were found for the scan-rescan and baseline-follow-up CSA comparisons, using the whole vessel length or single cervical level measurements. ICC analysis showed good degree of scan-rescan reproducibility (considering whole vessel measures: ICC > .9, P-value < .001 for CCA-ICAs, ICC > .6, P-value < .001 for VAs, and ICC > .7, P-value < .001 for IJVs). CONCLUSIONS: Scan-rescan reproducibility of CCA-ICAs, VAs, and IJVs CSA measurements is high, making longitudinal studies feasible.

Original languageEnglish
JournalJournal of Neuroimaging
DOIs
Publication statusE-pub ahead of print - Dec 2017

Fingerprint

Jugular Veins
Vertebral Artery
Common Carotid Artery
Internal Carotid Artery
Neck
Magnetic Resonance Imaging
Longitudinal Studies
Magnetic Resonance Angiography
Nonparametric Statistics
Respiration
Datasets

Keywords

  • Cross-sectional area
  • Internal carotid artery
  • Internal jugular vein
  • Magnetic resonance angiography
  • Scan-rescan reproducibility
  • Vertebral artery

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Neck Vessel Cross-Sectional Area Measured with MRI : Scan-Rescan Reproducibility for Longitudinal Evaluations. / Pelizzari, Laura; Laganà, Maria Marcella; Jakimovski, Dejan; Bergsland, Niels; Hagemeier, Jesper; Baselli, Giuseppe; Zivadinov, Robert.

In: Journal of Neuroimaging, 12.2017.

Research output: Contribution to journalArticle

Pelizzari, Laura ; Laganà, Maria Marcella ; Jakimovski, Dejan ; Bergsland, Niels ; Hagemeier, Jesper ; Baselli, Giuseppe ; Zivadinov, Robert. / Neck Vessel Cross-Sectional Area Measured with MRI : Scan-Rescan Reproducibility for Longitudinal Evaluations. In: Journal of Neuroimaging. 2017.
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abstract = "BACKGROUND AND PURPOSE: The cross-sectional area (CSA) of common carotid arteries-internal carotid arteries (CCA-ICAs), vertebral arteries (VAs), and internal jugular veins (IJVs) is influenced by aging. However, the neck vessel CSA can be affected by other factors as well, including subject positioning, hydration, and respiration, especially in longitudinal studies. This study aimed to assess scan-rescan reproducibility of CCA-ICAs, VAs, and IJVs CSA measurements in order to evaluate their feasibility for longitudinal CSA assessments, and to apply the segmentation method on a longitudinal pilot dataset. METHODS: Two set of 2-dimensional neck magnetic resonance angiography (MRA) images were acquired on a 3-T scanner from two separate datasets: 9 healthy individuals (HIs) were scanned 5 days apart (scan-rescan dataset) and 12 HIs were acquired 5 years apart (baseline-follow-up dataset). CCA-ICAs, VAs, and IJVs were segmented along the whole vessel length between C3 and C7 intervertebral spaces. Repeated measure analysis of covariance, adjusted for cervical level and sample, and Wilcoxon signed-rank sum test were used to assess the scan-rescan and baseline-follow-up CSA differences. Intraclass correlation coefficient (ICC) was also computed to evaluate scan-rescan reliability. RESULTS: No significant CSA differences were found for the scan-rescan and baseline-follow-up CSA comparisons, using the whole vessel length or single cervical level measurements. ICC analysis showed good degree of scan-rescan reproducibility (considering whole vessel measures: ICC > .9, P-value < .001 for CCA-ICAs, ICC > .6, P-value < .001 for VAs, and ICC > .7, P-value < .001 for IJVs). CONCLUSIONS: Scan-rescan reproducibility of CCA-ICAs, VAs, and IJVs CSA measurements is high, making longitudinal studies feasible.",
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T1 - Neck Vessel Cross-Sectional Area Measured with MRI

T2 - Scan-Rescan Reproducibility for Longitudinal Evaluations

AU - Pelizzari, Laura

AU - Laganà, Maria Marcella

AU - Jakimovski, Dejan

AU - Bergsland, Niels

AU - Hagemeier, Jesper

AU - Baselli, Giuseppe

AU - Zivadinov, Robert

PY - 2017/12

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N2 - BACKGROUND AND PURPOSE: The cross-sectional area (CSA) of common carotid arteries-internal carotid arteries (CCA-ICAs), vertebral arteries (VAs), and internal jugular veins (IJVs) is influenced by aging. However, the neck vessel CSA can be affected by other factors as well, including subject positioning, hydration, and respiration, especially in longitudinal studies. This study aimed to assess scan-rescan reproducibility of CCA-ICAs, VAs, and IJVs CSA measurements in order to evaluate their feasibility for longitudinal CSA assessments, and to apply the segmentation method on a longitudinal pilot dataset. METHODS: Two set of 2-dimensional neck magnetic resonance angiography (MRA) images were acquired on a 3-T scanner from two separate datasets: 9 healthy individuals (HIs) were scanned 5 days apart (scan-rescan dataset) and 12 HIs were acquired 5 years apart (baseline-follow-up dataset). CCA-ICAs, VAs, and IJVs were segmented along the whole vessel length between C3 and C7 intervertebral spaces. Repeated measure analysis of covariance, adjusted for cervical level and sample, and Wilcoxon signed-rank sum test were used to assess the scan-rescan and baseline-follow-up CSA differences. Intraclass correlation coefficient (ICC) was also computed to evaluate scan-rescan reliability. RESULTS: No significant CSA differences were found for the scan-rescan and baseline-follow-up CSA comparisons, using the whole vessel length or single cervical level measurements. ICC analysis showed good degree of scan-rescan reproducibility (considering whole vessel measures: ICC > .9, P-value < .001 for CCA-ICAs, ICC > .6, P-value < .001 for VAs, and ICC > .7, P-value < .001 for IJVs). CONCLUSIONS: Scan-rescan reproducibility of CCA-ICAs, VAs, and IJVs CSA measurements is high, making longitudinal studies feasible.

AB - BACKGROUND AND PURPOSE: The cross-sectional area (CSA) of common carotid arteries-internal carotid arteries (CCA-ICAs), vertebral arteries (VAs), and internal jugular veins (IJVs) is influenced by aging. However, the neck vessel CSA can be affected by other factors as well, including subject positioning, hydration, and respiration, especially in longitudinal studies. This study aimed to assess scan-rescan reproducibility of CCA-ICAs, VAs, and IJVs CSA measurements in order to evaluate their feasibility for longitudinal CSA assessments, and to apply the segmentation method on a longitudinal pilot dataset. METHODS: Two set of 2-dimensional neck magnetic resonance angiography (MRA) images were acquired on a 3-T scanner from two separate datasets: 9 healthy individuals (HIs) were scanned 5 days apart (scan-rescan dataset) and 12 HIs were acquired 5 years apart (baseline-follow-up dataset). CCA-ICAs, VAs, and IJVs were segmented along the whole vessel length between C3 and C7 intervertebral spaces. Repeated measure analysis of covariance, adjusted for cervical level and sample, and Wilcoxon signed-rank sum test were used to assess the scan-rescan and baseline-follow-up CSA differences. Intraclass correlation coefficient (ICC) was also computed to evaluate scan-rescan reliability. RESULTS: No significant CSA differences were found for the scan-rescan and baseline-follow-up CSA comparisons, using the whole vessel length or single cervical level measurements. ICC analysis showed good degree of scan-rescan reproducibility (considering whole vessel measures: ICC > .9, P-value < .001 for CCA-ICAs, ICC > .6, P-value < .001 for VAs, and ICC > .7, P-value < .001 for IJVs). CONCLUSIONS: Scan-rescan reproducibility of CCA-ICAs, VAs, and IJVs CSA measurements is high, making longitudinal studies feasible.

KW - Cross-sectional area

KW - Internal carotid artery

KW - Internal jugular vein

KW - Magnetic resonance angiography

KW - Scan-rescan reproducibility

KW - Vertebral artery

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